knightmare999
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POB posted a link that really describes SHBG in depth:
https://www.ncbi.nlm.nih.gov/pubmed/2080856
Information below has been pulled from the above document.
SHBG binds to testosterone, but it also bonds to other sex hormones (it was originally called "Testosterone-estradiol Binding Globulin). SHBG has an affinity for steroids (e.g., DHT, Testosterone, and e2).
SHBG suppression relative to the presence of testosterone is called the Free Androgen Index.
Calculating the Free Androgen Index can reveal hormonal anomalies that may escape detection via free testosterone measurement alone.
For those that have only considered SHBG in relation to testosterone levels (as I originally did), observe the following:
"""
Oestrogens administered orally are a more
powerful stimulant of SHBG synthesis than
those given percutaneously due to their direct
absorption into the portal system. Antioestrogens such as clomiphene and tamoxifen" also induce SHBG synthesis presumably as a result of their inherent weak oestrogenic activity.
Dexamethasone, progesterone and exogenous gonadotrophins have also been reported to increase SHBG concentration."""
--------
(The following is not from the document named above)
Masteron, Winstrol, and other DHT derivatives are known for their ability to bind to SHBG and, reportedly, increase free testosterone. This effect presumably indicates that DHT has a higher binding preference to SHBG than test.
What effects does this have on e2? Is DHT binding preferred above e2? Does increased free test also mean increased e2 (as e2 would also seemingly be unable to bind to SHBG already bound to Mast, etc.)
Would love to hear other thoughts on SHBG or additional insight from those more knowledgeable than myself on the subject.
Thanks.
https://www.ncbi.nlm.nih.gov/pubmed/2080856
Information below has been pulled from the above document.
SHBG binds to testosterone, but it also bonds to other sex hormones (it was originally called "Testosterone-estradiol Binding Globulin). SHBG has an affinity for steroids (e.g., DHT, Testosterone, and e2).
SHBG suppression relative to the presence of testosterone is called the Free Androgen Index.
Calculating the Free Androgen Index can reveal hormonal anomalies that may escape detection via free testosterone measurement alone.
For those that have only considered SHBG in relation to testosterone levels (as I originally did), observe the following:
"""
Oestrogens administered orally are a more
powerful stimulant of SHBG synthesis than
those given percutaneously due to their direct
absorption into the portal system. Antioestrogens such as clomiphene and tamoxifen" also induce SHBG synthesis presumably as a result of their inherent weak oestrogenic activity.
Dexamethasone, progesterone and exogenous gonadotrophins have also been reported to increase SHBG concentration."""
--------
(The following is not from the document named above)
Masteron, Winstrol, and other DHT derivatives are known for their ability to bind to SHBG and, reportedly, increase free testosterone. This effect presumably indicates that DHT has a higher binding preference to SHBG than test.
What effects does this have on e2? Is DHT binding preferred above e2? Does increased free test also mean increased e2 (as e2 would also seemingly be unable to bind to SHBG already bound to Mast, etc.)
Would love to hear other thoughts on SHBG or additional insight from those more knowledgeable than myself on the subject.
Thanks.