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Thread: Igf1lr3 & des

  1. #1
    Elite gymrat827's Avatar
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    Igf1lr3 & des

    Igf1LR3 and IGF1 Des are not exaclt the same. IGF1 des has a halflife of
    about 10-15min IGF1LR3 has an activelife of 20-30hrs.

    I personally love and rec the LR3 version over igf1 des ANY way. but some
    like ther igf1des and liek spot injections into each muscle.
    for me LR3 shot SubQ has giving great results and it ends up costign ALOT
    less the HGH <http://www.proteinpeptides.com/> and i find give MORE results
    and is run only at a fraction of the time for them compared to
    HGH<http://www.proteinpeptides.com/>
    .

    Yes I would run them together.
    but for me i would most likly use just ghrp6 + IGF1LR3. but i dotn see a res
    why you couldent.

    *here is some info on LR3 and DES:*

    IGF stands for insulin-like growth factor. Insulin-like growth factor 1 (
    igf-1 <http://www.igf-1info.com/>) is a polypeptide protein hormone similar
    in molecular structure to insulin . It plays an important role in childhood
    growth and continues to have effects in adults. It is a natural substance
    that is produced in the human body and is at its highest natural levels
    during puberty. During puberty IGF is the most responsible for the natural
    muscle growth that occurs during these few years. There are many different
    things that IGF does in the human body. Among the effects the most positive
    are increased amino acid transport to cells, increased glucose transport,
    increased protein synthesis, decreased protein degradation, and increased
    RNA synthesis.
    Long R3 igf-1 <http://www.igf-1info.com/> is signifacantly more potent than
    igf-1 <http://www.igf-1info.com/>. The enhanced potency is due to the
    decreased binding of Long R3 igf-1 <http://www.igf-1info.com/> to all known
    IGF binding proteins. These binding proteins normally inhibit the biological
    actions of IGF's. When IGF is active it behaves differently in different
    types of tissues. In muscle cells proteins and associated cell components
    are stimulated. Protein synthesis is increased along with amino acid
    absorption. As a source of energy, IGF mobilizes fat for use as energy in
    adipose tissue. In lean tissue,

    IGF prevents insulin from transporting glucose across cell membranes. As a
    result the cells have to switch to burning off fat as a source of energy.
    IGF also mimic's insulin in the human body. It makes muscles more sensitive
    to insulin's effects, so if you are a person that currently uses insulin you
    can lower your dosage by a decent margin to achieve the same effects, and as
    mentioned IGF will keep the insulin from making you fat.
    The most effective form of IGF is Long R3 igf-1 <http://www.igf-1info.com/>,
    it has been chemically altered and has had amino acid changes which cause it
    to avoid binding to proteins in the human body and allow it to have a much
    longer half life, around 20-30 hours. "Long R3
    igf-1<http://www.igf-1info.com/>is an 83 amino acid analog of
    igf-1 <http://www.igf-1info.com/> comprising the complete human
    igf-1<http://www.igf-1info.com/>sequence with the substition of an
    Arg(R) for the Glu(E) at position three,
    hence R3, and a 13 amino acid extension peptide at the N terminus. This
    analog of igf-1 <http://www.igf-1info.com/> has been produced with the
    purpose of increasing the biological activity of the IGF peptide."
    IGF Cycles
    The most effective length for a cycle of IGF is 50 days on and 20-40 days
    off. The most controversy surrounding Long R3
    igf-1<http://www.igf-1info.com/>is the effective dosage.
    IGF Dosage
    The most used dosages range between 20mcg/day to 120+mcg/day. IGF is only
    available by the milligram, one mg will give you a 50 day cycle at
    20mcg/day, 2mg will give you a 50 day cycle at 40mcg/day, 3mg will give you
    a 50 day cycle at 60mcg/day, 4mg will give you a 50 day cycle at 80mcg/day
    and so on. The dosage issue mainly revolves around how much money you have
    to spend, plenty of people use the minimum dosage of 20mcg/day and are happy
    with the results. IGF is most effective when administered subcutaneous and
    injected once or twice daily at your current dosage. The best time for
    injections is either in the morning and/or immediately after weight training
    (if used for body building).
    IGF Effects and Results
    Perhaps the most interesting and potent effect IGF has on the human body is
    its ability to cause hyperplasia, which is an actual splitting of cells.
    Hypertrophy is what occurs during weight training and steroid use, it is
    simply an increase in the size of muscle cells. See, after puberty you have
    a set number of muscle cells, and all you are able to do is increase the
    size of these muscle cells, you don't actually gain more. But, with IGF use
    you are able to cause this hyperplasia which actually increases the number
    of muscle cells present in the tissue. So in a way IGF can actually change
    your genetic capabilities in terms of muscle tissue and cell count. IGF
    proliferates and differentiates the number of types of cells present. At a
    genetic level it has the potential to alter an individuals capacity to build
    superior muscle density and size.

    Another frequently asked question of IGF refers to the real world results.
    With an effective dosage you can expect to gain 1-2 lbs of new lean muscle
    tissue every 2-3 weeks. Increased vascularity is also very common, people
    report seeing veins appear where they never have before.
    Overall, IGF is a very exciting drug due to its ability to alter ones
    genetic capabilities.


    Beginner’s Guide To IGF1-lr3
    ________________________________________
    The goal of this guide is to help both those that have not used
    igf-1LR3<http://www.igf-1info.com/>before and for those that simply
    would like a methodical approach to the
    “mechanics” of running it. This guide does not expand on the biochemistry of
    igf-1 <http://www.igf-1info.com/>, aside from a very simple introduction to
    it. I suggest reading a book or searching forums to educate yourself about
    the biochemistry of “peptides” or “IGF” if you require in-depth knowledge.

    I am not a physician, thus cannot and do not diagnose ailments or diseases
    and/or nor do I suggest that igf-1 <http://www.igf-1info.com/> is a remedy
    for any illness or diseases. igf-1 <http://www.igf-1info.com/> should be
    treated with much respect. It is research compound, thus you should use at
    your own risk.

    Currently (05/31/2008), in the United States,
    igf-1LR3<http://www.igf-1info.com/>is a research compound. It is legal
    to own this substance to the best of my
    knowledge (at current time). I am not an attorney, so please review your
    local law(s) regarding possession and administration of this therapeutic
    protein.

    I do not condone the usage of igf-1LR3 <http://www.igf-1info.com/> unless
    you are qualified to do so. This guide is provided as a research &
    development tool only.

    igf-1LR3 <http://www.igf-1info.com/> Overivew

    Background:
    Long Arg3 Insulin-like Growth Factor-I (Long-R3-IGF-I) is an 83 amino acid
    analog of IGF-I comprising the complete IGF-I sequence with the substitution
    of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid
    extension peptide at the N-terminus. Long-R3-IGF-I is significantly more
    potent than IGF-I in vitro. The enhanced potency is due to the markedly
    decreased binding of Long-R3-IGF-I to IGF binding proteins which normally
    inhibit the biological actions of IGFs.



    Description:
    Recombinant Human Long-R3-IGF-I produced in E. coli is a single,
    non-glycosylated, polypeptide chain containing 83 amino acids and having a
    molecular mass of 9111 Dalton.



    0.6% Acetic Acid Overview
    Acetic Acid (AA) will be used to reconstitute (turn your lyophilized
    igf-1<http://www.igf-1info.com/>into a liquid form) your
    igf-1 <http://www.igf-1info.com/>. The standard is to use 0.6% AA. This
    concentration is typically not available for you to purchase. You can make
    your own 0.6% AA and I will show you how below (many have used this method
    successfully).

    Making 0.6% Acetic Acid
    You will have to purchase a few items upfront. Here is a “grocery list” of
    items you will need. I have provided check boxes for you to check off once
    you have purchased these items.

    Items Needed:
    • Distilled white vinegar (grocery store)
    • Distilled water (grocery store)
    • 0.2-0.22um sterile Whatman syringe filter
    • 10mL syringe with a luer lock tip
    • ~20-22 gauge needles (just the needles)
    • Sterile glass vial (10-20mL)
    • Alcohol prep pads – sterile kind (70% isopropyl alcohol)


    Quick Guide:
    1. Swab the top of your sterile vial with alcohol prep pad (70% isopropyl
    alcohol)
    2. Mix 7.5mL distilled water with 1.0mL vinegar
    3. Add Whatman syringe filter
    4. Add sterile ~20ga. needle to end of Whatman filter
    5. Inject the 8.5mL of solution into the sterile vial
    6. You now have sterile 0.6% acetic acid



    Detailed Directions:
    1. Wash you hands thoroughly
    2. Optional: wear alcohol treated exam gloves (rub your gloved hands
    together with 70% isopropyl alcohol on them until dry)
    3. Using a sterile alcohol prep pad, swab the top of your sterile glass vial
    (into which the acetic acid solution will be held in)
    4. Using the 10mL syringe with a ~20ga. needle on the end, draw up 7.5mL
    distilled water
    5. Using the same syringe, now draw up 1mL vinegar
    6. Remove needle from the syringe and discard
    7. Attach 0.2-0.22um Whatman sterile syringe filter (do not touch the free
    end that will have a needle on it)
    8. Put a new, sterile needle (~20 gauge) onto the free end of the Whatman
    filter (do not touch needle)
    a. Do not use the same needle on the Whatman that was used to originally
    draw up the unsterile vinegar and distilled water.
    9. Put a ~20 gauge sterile needle into the top of your sterile glass vial to
    act as a vent
    10. Inject the acetic acid solution into the vial
    11. You are now done and should have sterile 0.6% acetic acid

    Notes:
    1. These items MUST be sterile: 20-22ga. Needles, whatman filter, glass vial
    2. Whatman filter: These small, sterile filters are used to filter the
    acetic acid solution so it is sterile. It does not matter that the liquid in
    your syringe (distilled water & vinegar) is not sterile, nor does it matter
    that the syringe itself is not sterile. Once the liquid goes through the
    filter it is STERILE. Thus, everything after the filter must be sterile!
    3. You will most likely use 1mL (milliliter) of 0.6% AA to reconstitute your
    igf-1 <http://www.igf-1info.com/>. Thus, you should make at least 1.5mL. In
    reality, it’s just as easy to make 8.5mL as I have stated in the above
    directions. You will have plenty for use later then.
    4. Do NOT reuse the Whatman filter nor any needles! Discard immediately.




    Reconstituting igf-1LR3 <http://www.igf-1info.com/>
    Reconstitution is simply the addition of the 0.6% AA to your lyophilized
    igf-1 <http://www.igf-1info.com/>.
    Assumption: 1mg/mL igf-1 <http://www.igf-1info.com/>/AA (1mg
    igf-1<http://www.igf-1info.com/>will be combined with 1mL AA; 1mg
    igf-1 <http://www.igf-1info.com/> is the same as 1,000mcg)

    1. Swab the top of your igf-1 <http://www.igf-1info.com/> vial with a
    sterile alcohol prep pad
    2. Swab the top of your 0.6% AA vial with a sterile alcohol prep pad
    3. Using either multiple insulin syringe volumes (example: 2 x 0.5cc) or a
    single large syringe, obtain 1.0mL of 0.6% AA.
    4. In the igf-1 <http://www.igf-1info.com/> vial, insert a sterile ~20 ga.
    needle to act as a vent
    5. Inject the 1.0mL of AA very slowly and dribble it down the side of the
    vial.
    a. Be very careful with this peptide as it is very delicate!
    6. Remove the needle & syringe and discard
    7. Gently swirl the vial or roll between your hands.
    a. Again, be very gentle here
    8. You now have 1mg/mL of igf-1 <http://www.igf-1info.com/>
    a. This is the same as: 1,000mcg/mL

    Notes:
    1. If you added 2mL of AA, it would be a 0.5mg/mL
    2. I have an Excel calculator that will help you with these calculation.


    Injecting igf-1LR3 <http://www.igf-1info.com/>
    If this is your first time with injections, don’t worry. You will be using a
    very fine gauge insulin syringe which means you will most likely have nearly
    effortless injections. These things are so tiny and sharp you may not even
    feel it penetrating. If you use sterile procedure, aspirate prior to
    injection, and have diluted your igf-1 <http://www.igf-1info.com/>/AA
    solution with enough bacteriostatic water (BW), you should have no issues
    with your injections and very minimal post-injection discomfort (if any at
    all!).

    I cannot stress enough the importance on two topics: A) sterility, and B)
    pre-injection aspiration. Always swab the injection site(s) with a sterile
    isopropyl alcohol (IPA) pad and aspirate prior to injecting the
    igf-1<http://www.igf-1info.com/>.
    No questions asked!

    You will most likely intramuscular (IM) injections, but subcutaneous (sub-q)
    injections are also followed by some, but current theory is that IM will
    yield a localized effect. By “localized effect”, I am referring to the
    effect igf-1 <http://www.igf-1info.com/> will have at the injection site. So
    if you inject IM into biceps, it is thought that your bicep muscles will get
    more of a dose of igf-1 <http://www.igf-1info.com/> than other parts of your
    body (some which you don’t want to be effected, such as the intestines).
    Both types of injections will have systemic effects (affecting the body as a
    whole). Long R3 igf-1 <http://www.igf-1info.com/> has an estimated half-life
    of 20-30hrs (taken from IGTROPIN data).

  2. #2
    Elite Fsuphisig's Avatar
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    What do yu mean by aspirating ?

  3. #3
    Senior Member shenky's Avatar
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    Originally Posted by Fsuphisig View Post
    What do yu mean by aspirating ?
    prior to pushing in plunger during injection, slightly pulling plunger up to see ensure you are not drawing blood.

  4. #4
    Elite Fsuphisig's Avatar
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    Ok ok I thought that was called back loading or something thanks

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