Results 1 to 2 of 2
  1. #1
    Super Moderator gymrat827's Avatar
    Join Date
    Dec 2011
    Location
    shy town
    Posts
    5,155
    Thanks
    109
    Thanked 844 Times in 614 Posts

    Clenbuterol Write Up

    Clenbuterol is an anti asthma medication that belongs to a broad group of drugs known as sympathomimetics. These drugs affect that sympathetic nervous system in a wide number of ways, largely mediated by the distribution of adrenoceptors. There are actually nine different types of these receptors in the body, which are classified as either alpha or beta and further subcategorized by type number of ways, largely mediated by the distribution of adrenoceptors. Clenbuterol has been available as a bronchodilator for decades and is widely used in many parts of the world. Although it has a good safety record and approval in a wide number of other countries, this compound has never been made available for human use in the United States. The fact that there are a number of similar effective asthma medications already approved by the FDA and available may have something to do with this.

    In terms of the use of clenbuterol for strength athletes and bodybuilders, its function as a beta-2 agonist can help to increase lypolysis. This is accomplished via an increase in basal metabolic rate, as well as increased heat production in the mitochondria which serves to increase body temperature and therefore increasing thermogenesis. Addtionally, it has been shown that clenbuterol is able to directly stimulate fat cells and accelerate the breakdown of triglycerides, thus forming free fatty acids. All of this is accomplished while clenbuterol has a minimal effect on the user cardiovascularly. This, as stated previously, is due to the drug being a selective beta-2 agonist/antagonist and having a minimal impact on the beta-1 receptors. This should cause less negative side effects, at least cardiovascularly, for the user. A second benefit to the administration of clenbuterol for athletes is an increase in strength as well as a possible increase in muscle size/lean body mass. It has been repeatedly demonstrated in animal studies that clenbuterol contributes to an increase in muscle mass, weight and protein content. The exact mechanism by which this takes place has still not been definitively identified but it can be concluded that it is far different then the response produced by anabolic steroids. Like other beta-2 agonists, clenbuterol has also been shown to increase muscular strength. Again, these results were achieved in animal studies but there is little reason to believe would not be transferable to human users. These gains are made over time and not a result of any type of stimulatory effect of the drug. Again however, the exact mechanism by which these results are achieved with clenbuterol is not known. It is not the same as anabolic steroids but more research needs to be done before a full understanding of this mechanism is known. Clenbuterol does increase muscle protein synthesis so this is likely to contribute but is unlikely to be the only cause. Clenbuterol has an array of potential negative side effects that are indicated in the available research, most of which has been performed using animals. The problem with this is the fact that animals have quite different beta-2 receptor reactions then humans in some cases as well as having a larger quantity of these receptors in the relevant tissues. This obviously could lead to differing reactions in humans then those found in various animals. However due to the lack of research available conducted with human subjects, we are left to decipher the applicability of the animal research that has been conducted. The most commonly reported side effects associated with clenbuterol are tremors, increased heart rate, increased sweating, restlessness, headaches, and loss of appetite. The only way to prevent or reduce such symptoms from occurring is to either reduce the dosing being administered or ceasing to use the drug completely.



    Athletes and bodybuilders taking clenbuterol to lose body fat usually take 1-3 40mcg pills per day with the dosage usually being split up. The receptors will eventually get used to the drug and some time should be taken off to allow them to down regulate. Because of this many choose to run a 2 week on and 2 week off schedule.

  2. #2
    Super Moderator gymrat827's Avatar
    Join Date
    Dec 2011
    Location
    shy town
    Posts
    5,155
    Thanks
    109
    Thanked 844 Times in 614 Posts

    Re: Clenbuterol Write Up

    What is Clenbuterol?

    Clenbuterol is a beta-2 agonist and is used in many countries as a broncodilator
    for the treatment of asthma. Because of it's long half life, clenbuterol is not
    FDA approved for medical use. It is a central nervous system stimulant and acts
    like adrenaline. It shares many of the same side effects as other CNS stimulants
    like ephedrine. Contrary to popular belief, Clenbuterol has a half life of 35
    hours and not 48 hours.

    Dosing and Cycling



    Clenbuterol comes in 20mcg tablets, although it is also available in syrup, pump
    and injectable form. It's also available as a powder in some areas. Doses are
    very dependent on how well the user responds to the side effects, but somewhere
    in the range of 4-8 tablets per day for men and 2-4 tablets a day for women is
    most common. Clenbuterol loses its thermogenic effects after around 8 weeks when
    body temperature drops back to normal. Its anabolic/anti-catabolic properties
    fade away at around the 18 day mark. Taking the long half life into
    consideration, the most effective way of cycling Clen is 2 weeks on/ 2 weeks off
    for no more than 12 weeks. Ephedrine or Yohimbine can be used in the off weeks.

    Clenbuterol vs Ephedrine vs DNP

    Ephedrine will raise metabolic levels by about 2-3 percent and 200mg of DNP
    raises metabolic levels by about 30 percent. Clenbuterol raises metabolic levels
    about 10 percent and it can raise body temperature several degrees.

    DNP is by far the most effective fat burner but many people will never use it
    because of the risks associated with it. It also offers no anti-catabolic
    benefit. Although it does have anti-catabolic effect, ephedrine's short
    half-life prevents it from being all that effective.

    As far as side effects, Clenbuterol's are certainly milder than DNP's, and some
    would even say milder than an ECA stack. There is no ECA-style crash on
    Clenbuterol and many users find it easier on the prostate and sex drive. This
    may in part be due to the fact that Clen is generally used for only 2 weeks at a
    time.

    Side effects

    NAUSEA
    NERVOUSNESS
    DIZZINESS
    DROWSINESS
    DRY MOUTH
    FACIAL FLUSHING
    HEADACHE
    HEARTBURN
    INCREASED BLOOD PRESSURE
    INCREASED SWEATING
    INSOMNIA
    LIGHTHEADEDNESS
    MUSCLE CRAMPS
    TREMORS
    VOMITING
    CHEST PAIN

    The most significant side effects are muscle cramps, nervousness, headaches, and
    increased blood pressure.

    Muscle cramps can be avoided by drinking 1.5-2 gallons of water and consuming
    bananas and oranges or supplementing with potassium tablets at 200-400mg a
    day taken before bed on an empty stomach. Taurine at 3-5grams is a necessity in
    minimizing cramps.

    Headaches can easily be avoided with Tylenol Extra Strength taking at the first
    signs of a headache.

    Common Uses

    post-cycle Therapy: Clen is used post cycle to aid in recovery. It allows the
    user to continue eating large amounts of food, without worrying about adding
    body fat. It also helps the user maintain more of his strength as well as his
    intensity in the gym. Diet: Roughly the same as on cycle.

    Fat loss: The most popular use for Clen, it also increases muscle hardness,
    vascularity, strength and size on a caloric deficit. For the most significant
    fat loss, Clen can be stacked with T3. Diet: A high protein(1.5g per lb of
    bodyweight), moderate carb(0.5g to 1g per lb of bodyweight), low fat diet(0.25g
    per lb of bodyweight) seems to work best with Clen.

    Alternative to Steroids: Clenbuterol has mild steroid-like properties and can be
    used by non-AS using bodybuilder to increase LBM as well as strength and muscle
    hardness. Diet: A moderate carb, high protein, moderate fat diet work well.

    Stimulant/Performance Enhancement: It can be used as a stimulant, but an ECA
    stack may be a better choice because of it's much shorter half-life. Diet: To
    take full advantage of the stimulatory effects of Clen, carbohydrates must be
    included in the diet. Ketogenic diets do not work well in this case.

    Precautions: Is Clen for you?

    The same precautions that apply to Ephedrine must be applied to Clen, although
    some people find ECA stacks are harsher than Clen. It should not be stacked
    with other CNS stimulants such as Ephedrine and Yohimbine. These combinations
    are unnecessary and potentially dangerous. Caffeine can be used in moderation
    before a workout for an extra quick. burst of energy.

    A word on Ketotifen

    Ketotifen is safe antihistamine used extensively some European countries to
    treat asthma and allergies. It can up regulate beta-2-receptors that Clen down
    regulates. Basically, it allows users to extend their use of Clen for 6-8 weeks
    at a time. 2-3mg a day is ideal, 10mg as found in "superclen" can make users
    extremely drowsy. It also increases the effectiveness of Clen so doses must be
    adjusted accordingly. The downfall of this drug is its ability to induce
    extreme hunger is some people, which is not a desirable state to be in when
    dieting.

    Cycling Clenbuterol

    Most users that report bad side effects and discontinue use are those who use
    high doses right at the start of the cycle. The worst side effects occur within
    the first 3-4 days of use.

    A first time user should not exceed 40mcg the first day. Increase by one tab
    until the side effects are not tolerable

    Example of a first cycle:

    Day1: 20mcg
    Day2: 40mcg
    Day3: 60mcg
    Day4: 80mcg
    Day5: 80mcg(Note: Increase the dose only when the side effects are tolerable)
    Day6-Day12: 100mcg
    Day13: 80 mcg (Tapering is not necessary, but it helps some users get back to
    normal gradually)
    Day14: 60 mcgs
    Day15: off
    Day16: off
    Day 17: ECA/ NYC stack

    Example of a second cycle:

    Day1: 60mcg
    Day2: 80mcg
    Day3: 80mcg
    Day4: 100mcg
    Day5: 100mcg
    Day6-Day12: 120mcg
    Day13: 100 mcg
    Day14: 80 mcgs
    Day15: off
    Day16: off
    Day 17: ECA/ NYC stack

    What else do I need to know?

    Taurine MUST be used with Clen at 3-5g daily. Clenbuterol depletes taurine
    levels in the Liver which stops the conversion of T4 to T3 in the Liver.
    Taurine allows the user to avoid the dreaded rebound effect and painful muscle
    cramps. It's a must with Clen.

    Clenbuterol should not be taken too close to a workout. It can interfere with
    your breathing and complete ruin your workout. When doing cardio, it's
    advisable to stay at a consistent pace and avoid HIIT style routines.

    Do not take Clen Past 4pm and drink plenty of water; 1.5-2 gallons a day.

  3. The Following User Says Thank You to gymrat827 For This Useful Post:

    Beast78 (03-10-2017)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •