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  1. #1
    Senior Member ripped_one's Avatar
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    12 week study on Ostarine

    http://www.ncbi.nlm.nih.gov/pubmed/22031847

    BACKGROUND:

    Cachexia, also known as muscle wasting, is a complex metabolic condition characterized by loss of skeletal muscle and a decline in physical function. Muscle wasting is associated with cancer, sarcopenia, chronic obstructive pulmonary disease, end-stage renal disease, and other chronic conditions and results in significant morbidity and mortality. GTx-024 (enobosarm) is a nonsteroidal selective androgen receptor modulator (SARM) that has tissue-selective anabolic effects in muscle and bone, while sparing other androgenic tissue related to hair growth in women and prostate effects in men. GTx-024 has demonstrated promising pharmacologic effects in preclinical studies and favorable safety and pharmacokinetic profiles in phase I investigation.

    METHODS:

    A 12-week double-blind, placebo-controlled phase II clinical trial was conducted to evaluate GTx-024 in 120 healthy elderly men (>60 years of age) and postmenopausal women. The primary endpoint was total lean body mass assessed by dual energy X-ray absorptiometry, and secondary endpoints included physical function, body weight, insulin resistance, and safety.

    RESULTS:

    GTx-024 treatment resulted in dose-dependent increases in total lean body mass that were statistically significant (P < 0.001, 3 mg vs. placebo) and clinically meaningful. There were also significant improvements in physical function (P = 0.013, 3 mg vs. placebo) and insulin resistance (P = 0.013, 3 mg vs. placebo). The incidence of adverse events was similar between treatment groups.

    CONCLUSION:

    GTx-024 showed a dose-dependent improvement in total lean body mass and physical function and was well tolerated. GTx-024 may be useful in the prevention and/or treatment of muscle wasting associated with cancer and other chronic diseases.

  2. #2
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    Re: 12 week study on Ostarine

    i am looking into all this new stuff on the market, SARMS, peptides........etc..........all new to me.

    might have to give it a go when i have money

  3. #3
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    Re: 12 week study on Ostarine

    I am looking into finding a way to make a SARM into an oral suspension, like with cyclodextrin maybe.
    Not finding much. Not even necessary actually since SARMs are already dosed effectively, but it will be fun.

  4. #4
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    Re: 12 week study on Ostarine

    hey flex, u down to do some business together bro?

    im open for business if ur up for it

  5. #5
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    Re: 12 week study on Ostarine

    Let's make some SARMs!!!

  6. #6
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    Re: 12 week study on Ostarine

    right on bro...........let make it global dude............im in denmark now.

    imma try to get my girl out here soon, but in the meantime i want to set up shop with the supp companies out here. feel em out and how down they are..........

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