Results 1 to 8 of 8
  1. #1
    Elite Viduus's Avatar
    Join Date
    Feb 2018
    Location
    Upper Midwest
    Posts
    1,115
    Thanks
    778
    Thanked 1,018 Times in 594 Posts

    NY Times - SARMs Article

    https://mobile.nytimes.com/2018/04/1...ts-safety.html

    A Better Body in a Pill? Experts Urge Caution on SARMs

    Anahad O’Connor

    Many athletes and gym-goers are turning to a popular but potentially dangerous new pill to help them build muscle and gain strength: a steroid alternative known as SARMs.

    The pills are widely marketed online as “legal steroids” that provide the muscle-building benefits of anabolic steroids without the troubling side effects. And while the products are legal — at least so far — their spread has alarmed health authorities, who say they are not necessarily safe.

    Drug companies developed SARMs, which stands for selective androgen receptor modulators, as an alternative to anabolic steroids for people who suffer from age and disease-related muscle loss. But they are the subject of ongoing clinical trials and have not been approved for use by the Food and Drug Administration.

    In October, the agency issued a public advisory cautioning that SARMs were unapproved drugs linked to “serious safety concerns,” including the potential for an increased risk of liver toxicity, heart attacks and strokes.

    A month later, a study published in JAMA revealed that products marketed as SARMs were frequently misbranded and tainted with unlisted ingredients. Out of 44 products that were purchased online and analyzed, only about half contained an actual SARM, while 10 percent contained none at all. Roughly 40 percent had other hormones and unapproved drugs. Several contained a drug that was abandoned by GlaxoSmithKline a decade ago after it was found to cause cancer in animals.

    The long-term consequences of using SARMs are largely unknown, and people who purchase products marketed as them cannot be entirely sure what they are putting in their bodies, said Dr. Shalender Bhasin, the director of research programs in men’s health, aging and metabolism at Brigham and Women’s Hospital and an author of the JAMA report.

    “We don’t know whether these compounds are safe,” he said, “but we do know that some of them have side effects.”

    That has not stopped many people from experimenting with them.

    Thaddeus Owen, 42, a self-described biohackerwho lives in Saint Paul, Minn., began using SARMs in 2016 in combination with a diet and exercise program. He said that the pills helped him pack on five pounds of muscle in four weeks, which he documented on his website, “PrimalHacker.” He argued that informed adults should be allowed “to experiment on ourselves and improve our biology,” but added, “this is definitely a use-at-your-own-risk type of supplement.”

    Anti-doping officials have known about SARMs for some time and have seen an increasing number of elite athletes using them. Since 2015, the United States Anti-Doping Agency has imposed sanctions on more than two dozen track and field stars, weight lifters, cyclists, mixed martial artists and others for testing positive for a variety of SARMs, most frequently one called ostarine.

    Last year, Joakim Noah, a center for the New York Knicks, was suspended for 20 games for testing positive for a SARM. The college basketball star Allonzo Trier of the Arizona Wildcats was also suspended for using SARMs. And in October, a top CrossFit Games competitor, Ricky Garard, was stripped of his third-place title after testing positive for two SARMs: ostarine and testolone.

    While the underground use of SARMs has made them controversial, the drugs could one day serve a crucial purpose for many patients.

    Scientists developed SARMs decades ago to counter the age-related decline in muscle and strength that tends to begin around middle age and that can contribute to falls and broken bones. Many chronic diseases, such as cancer, heart failure and kidney disease, are also punctuated by a loss of muscle and physical mobility.

    Anabolic and androgenic steroids such as testosterone can help people regain muscle and physical function. But they act on many tissues throughout the body and have been tied to a litany of potential side effects, including prostate problems and cardiovascular events.

    SARMs were designed to selectively target skeletal muscle and spare other tissues, in an attempt to reduce some of these unwanted side effects. A number of trials are looking at their usefulness in cancer patients, people recovering from hip surgery, and postmenopausal women with urinary incontinence linked to weak pelvic muscles.

    A three-week trial at Boston University demonstrated that LGD-4033, a SARM developed by Ligand Pharmaceuticals, was safe and tolerable in healthy men, producing “significant gains in muscle mass and strength” without raising levels of a protein linked to prostate cancer. But it had other effects as well, for instance causing a drop in HDL cholesterol, the protective kind, which raised questions about its effects on heart health.

    “Long-term studies are needed to clarify the effects of long-term SARM administration on cardiovascular risk,” the authors concluded.

    Thomas O’Connor, a doctor who founded a men’s health clinic and wrote a book called “America on Steroids,” said that many of his patients are anabolic steroid users who turned to SARMs because they were told that they were safe and nontoxic. He said that since 2010 has seen “hundreds, maybe over 1,000 men on SARMs” from all walks of life: police officers, defense workers, amateur athletes, accountants and others.

    It’s hard to determine the precise impact of SARMs because many people who use them combine them with other drugs, supplements and substances, Dr. O’Connor said. But one thing he often sees among people using SARMs is that their cholesterol profiles worsen and their liver enzymes rise, a sign of increased strain on their livers. Some also experience diminished sex drive, hair loss, acne and irritability, though it’s often difficult to know whether it’s the SARMs causing these symptoms or some other unlisted ingredients in the products.

    As a longtime power lifter, Dr. O’Connor said he relates to a lot of his patients and understands their desire to be bigger, stronger and fitter. But he counsels them to give up the drugs they are using because they are jeopardizing their health.

    “I always tell them the same thing,” he said. “These are illicit agents. They’re not supported by expert guidelines and they’re dangerous. So don’t take them.”

    The Council for Responsible Nutrition, a supplement industry trade group, launched a campaign on social media, #SARMSCanHarm, and is working with sports clubs, fitness groups and coaches around the country. The military and federal government also have an awareness campaign about risky products called Operation Supplement Safety.

    Patricia Deuster, a professor of military and emergency medicine at the Uniformed Services University of the Health Sciences, said SARMs are popular among some soldiers because they are easier to access than anabolic steroids, but she warns them there are hazards, citing one soldier who suffered liver damage and could not deploy with his unit because he was hospitalized after using a product containing SARMs and other ingredients.

    “We try to tell them that there are other ways that they can achieve their goals without risking their health or their ability to maintain their deployment status,” Dr. Deuster said. “We are trying to educate them.”
    Last edited by PillarofBalance; 04-12-2018 at 05:33 PM.
    “The only natural test-boosters I know of that work are compound lifting, steaks, and looking at boobies...” -Dan

  2. The Following 2 Users Say Thank You to Viduus For This Useful Post:

    Jin (04-12-2018),Robdjents (04-12-2018)

  3. #2
    Super Moderator Spongy's Avatar
    Join Date
    Apr 2012
    Posts
    3,211
    Thanks
    247
    Thanked 1,927 Times in 884 Posts
    Jesus Christ there's a ****ing online movement associated with this... #SARMsCanHarm

    Good read! Now every uninformed casual lifter will read this and think "5 pounds in 4 weeks? Sign me up!"
    In need of dieting help? Email me at [email protected]

  4. The Following 3 Users Say Thank You to Spongy For This Useful Post:

    automatondan (04-16-2018),Gibsonator (04-12-2018),Viduus (04-12-2018)

  5. #3
    Elite Gibsonator's Avatar
    Join Date
    Apr 2017
    Location
    Cali
    Posts
    3,062
    Thanks
    2,741
    Thanked 2,365 Times in 1,470 Posts
    yea viduus don't buy into the hype

  6. #4
    Elite Viduus's Avatar
    Join Date
    Feb 2018
    Location
    Upper Midwest
    Posts
    1,115
    Thanks
    778
    Thanked 1,018 Times in 594 Posts
    Quote Originally Posted by Gibsonator View Post
    yea viduus don't buy into the hype
    Never have, never will. Just saw it and wanted to share.
    “The only natural test-boosters I know of that work are compound lifting, steaks, and looking at boobies...” -Dan

  7. The Following 4 Users Say Thank You to Viduus For This Useful Post:

    automatondan (04-16-2018),BRICKS (04-12-2018),Gibsonator (04-12-2018),NbleSavage (04-12-2018)

  8. #5
    Administrator PillarofBalance's Avatar
    Join Date
    Feb 2012
    Posts
    19,138
    Thanks
    1,796
    Thanked 15,461 Times in 6,776 Posts
    Quote Originally Posted by Spongy View Post
    Jesus Christ there's a ****ing online movement associated with this... #SARMsCanHarm

    Good read! Now every uninformed casual lifter will read this and think "5 pounds in 4 weeks? Sign me up!"
    No shit... tl;dr society... this isn't helpful.

    But it does have some good lines I will use going forward when we inevitably get all these guys asking about them.
    "Overzealous dosing" -Jin

    Rest in Peace Robot Lord. First round of Natty Boh is on me when I make it up there with you brother.

  9. #6
    Super Moderator gymrat827's Avatar
    Join Date
    Dec 2011
    Location
    shy town
    Posts
    5,811
    Thanks
    141
    Thanked 1,212 Times in 884 Posts
    it would be interesting if people were able to get real stuff rather then watered down BS. Real stuff, like they test in labs would be interesting to see their effects, but its not like anyone is able to buy anything like that.

    I do believe they work..............just no one sells anything thats not cut like the cartel does to blow n shit.

    just like getting REAL LR3...

  10. #7
    Member
    Join Date
    Oct 2017
    Posts
    4
    Thanks
    0
    Thanked 0 Times in 0 Posts
    SOmething like this always comes along and guys who are just starting out want gains instantly and buy into the hype without any research into the consequences.

  11. #8
    Elite snake's Avatar
    Join Date
    Jan 2014
    Location
    North East
    Posts
    6,299
    Thanks
    4,134
    Thanked 7,550 Times in 3,263 Posts
    Quote Originally Posted by Spongy View Post
    Jesus Christ there's a ****ing online movement associated with this... #SARMsCanHarm

    Good read! Now every uninformed casual lifter will read this and think "5 pounds in 4 weeks? Sign me up!"
    Quote Originally Posted by PillarofBalance View Post
    No shit... tl;dr society... this isn't helpful.



    But it does have some good lines I will use going forward when we inevitably get all these guys asking about them.
    Thanks, you could have said something before I sent my money in! They said I can cancel my auto renew mailing after the first 6 months.
    Hard work beats talent when talent doesn’t work hard.

Similar Threads

  1. Different PCT times
    By ERandICU-RN in forum Post Cycle Therapy
    Replies: 16
    Last Post: 03-17-2014, 09:58 PM
  2. Detection times
    By animal87 in forum Anabolic Steroids
    Replies: 16
    Last Post: 01-12-2014, 12:18 AM
  3. Replies: 12
    Last Post: 11-16-2013, 01:48 AM
  4. Peak times for differenet insulins??
    By bubbagump in forum Insulin Discussion
    Replies: 6
    Last Post: 08-06-2013, 07:05 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •