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It's got nothing to do with pain for me. I just use the smallest gauge I can to keep scar tissue at a minimum. Of course I could use slin pins exclusively, but I'm not the most patient person, so 25g is a good compromise for me.
I rotate many injection sites as well. But considering I could potentially be injecting myself for 40 years or more I figure I'd try to keep scar tissue to a minimum.
I went from trt 2x/wk to once per week. I don't notice much of a difference.
I was using Cyp once a week, it was fine