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  1. #1
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    And Interesting Regarding Potential Prophylaxis against LVH

    This is an older study, but interesting nonetheless:



    https://www.ncbi.nlm.nih.gov/pubmed/2455168



    And some newer stuff:

    https://academic.oup.com/cardiovascr...45/1/79/416109


    Anybody here have experience with clonidine?


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  3. #2
    Senior Moderator NbleSavage's Avatar
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    Interesting study. Wondering if any of the Bros have experience with clonidine.
    "So make ya move and plead the Fifth cuz' ya can't plead the First..."
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    Well its a BP drug and if the LVH can be caused by high PB, I could see how it would make things better. I'm guessing here but if the heart reacts to stress like other muscles (2 different types of muscles) and there's less stress, things would return to near normal. Anyone that exercises will have some LVH but add in the gear and BB/PL should expect have a big issue. It would help if guys kept an eye on their BP. A few weeks is one thing but redlining it for 16 weeks 2x/year is not a good thing. Just my opinion.
    Hard work beats talent when talent doesn’t work hard.

  5. #4
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    What interests me is trying do distinguish between LVH caused by high bp/hematocrit and LVH caused by androgen and/or exercise-related anabolism in cardiac muscle.

    Seems to me as though the vast majority of LVH is caused by the former. As such, drugs like clonidine or even Cialis should offer effective prophylaxis against LVH.

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  7. #5
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    On the Cialis front:

    https://www.ncbi.nlm.nih.gov/pubmed/24271647 (study on the effects of tadalafil on LVDD)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204975/ (this is more of an overview)

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