Orals don’t work

Yaya

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I dont do orals anymore for years but they always were insane within days
 

metsfan4life

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ok so here is what I was sent about the possible reason and discussion that could bring up some really good insight on the subject. As far as who sent it, I will leave that up to them if they would like to post in the thread regarding this:

Reason 1: You are a CYP2D6/CYP2C19/CYP3A4 "ultra-rapid metabolizer". Your CYP liver enzymes metabolize the hormones too quickly for your body to have adequate exposure to the hormones. Patients taking CYP-mediated opioids like codeine, hydrocodone, etc are required higher dosages due to the ultra-rapid metabolizing.

Reason 2: You are ingesting things that affect your liver enzymes. Thus you are not getting adequate metabolism, and thus exposure, to the hormones.

Have you tried high-dosing the oral AAS? The first action to do is increase your dosage, due to #1 or #2. Titrate the dosages up until you find the dosage that gives effects.

Your liver should NOT be stressed more due to the increased dosages, due to the hyper-metabolizing of the compounds. I will find more reasona if need be. Those 2 I knew already.

Good luck, and have a great day


Did a little digging and its pretty interesting read, honestly, and could hold some weight. I posted just a few quick blurbs on the subject. Would love to see what anyone else comes up with and discussion on this as pretty interesting. I know for me - pain killers do nothing, had to take a few in the past for reasons and literally did nothing. The ONLY thing that has ever knocked me out is a high dosed suppository of Finnegan. I had to take my great gmas death bed pain killer once due to an issue - pretty much 2 doses of everything - it did nothing. Anyways...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975340/

https://www.pharmvar.org/gene/CYP2C19

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663206/
 

Jin

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Metsfan was buggered by a drunk Irish guy named Finnegan.
 

metsfan4life

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lolz!

Yep. Wisdom teeth out - 'you want percs or anything?" "nope, that shlit dothnt work"
 

RISE

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I cant get off to oral either.
 
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ECKSRATED

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Halo does nothing for me. Absolutely nothing.
 

metsfan4life

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Ok did some more discussion and I had always wondered about the metabolism issue if that could potentially be anything behind it or just a myth in my head. the more and more I read about it, its pretty interesting and does potentially answer some questions. additional input as in original had forgotten about the Poor Metabolisms which is pretty much what I believe I may be.

You are a poor metabolizer due to having ineffective enzyme variants. The other end of the spectrum.

  • Take 2 empty cups: Cup A and Cup B.
  • The cups=2 different variants of the human body.
  • Poke a large hole on the bottom of Cup A.
  • Poke a tiny hole on the bottom of Cup B.
  • The holes=metabolizing and excreting medicine.
  • Pour water into each cup.
  • Water=a compound (oral AAS, opioids, etc).

What happens? The water (medicine) in Cup A leaves the cup (human body) FASTER than the tiny hole in Cup B.

Ultra-rapid metabolizers are Cup A. Normal metabolizers are Cup B. Ultra-rapid metabolizers will NOT get an adequate body plasma concentration of a medicine-right after you take the medicine it's metabolized and excreted before it can build up in your body!

The same thing happens for those on the opposite end: those with inactive CYP enzymes. Compounds are excreted without being metabolized at all; ergo a person is void of any effect from ingesting the compounds.


So the more and more I read into it, I can easily start to put a few things together as there are a LOT of meds that simply have no effect on me, period, regardless of the amount I take. For the AAS, i get nothing from it period - oral or inject and wondering if that could be why. It seems that it sits there, and not used up and just excreted out. The blood levels for my liver during the extremely high doses were up there with obvious reason, however there was never any sides with the AAS such as the bloat, the back, the drive, or anything. The thing that makes me wonder now in general is if something like TNE has any effect as I get 0 from that as well.
But Jin, wondering
if you may be in the same boat as me with the orals since it seems nothing really works for you. Just wondering, have you ever tried the grapefruit thing? I know many on here have talked about it along with AAS but primarily with Rx meds that react. I have tried it several times at low do sage on the orals as well as high - just in case it worked. Took the GFJ and also 150 of dbol - same.

Anyways, pretty interesting topic. Thanks Jin for brining it up as brought some pretty good knowledge and discussion on here. And thinks to X for shooting me a quick PM that has brought some pretty good info!
 

metsfan4life

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Additional note: Even things like Viagra at 100mg has never had that effect on me, not even a headache. Now, not saying I need it but you know...for the random fun times on vacation. Didnt notice anything at 50mg (took 50mg due to many hating 100mg headaches) and felt nothing, not even a slight tingle (both heads), so took the other 50mg...nada. So starting trying the 100...nada. Decided to do 150....nada.
 

Beserker

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I cant get off to oral either.

Same here!

I never had any luck with Dbol or Drol either, and this was pharma grade over a decade ago. Painkillers, nothing. Test does work for me though. NSAIDs do also...
 

Seeker

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Same here!

I never had any luck with Dbol or Drol either, and this was pharma grade over a decade ago. Painkillers, nothing. Test does work for me though. NSAIDs do also...

lol I could be wrong but I think he was referring to something else. When you say pharma grade do you recall what pharma you were taking?
 

Maijah

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I've only used liquid orals, but they have worked excellent.
 

Beserker

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Haha Seek, I was referring to blow jobs then added my .02

Pink Thais, BD
 

Seeker

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Haha Seek, I was referring to blow jobs then added my .02

Pink Thais, BD

lol wow. I'm like a volcanic major eruption on oral. Haha lava everywhere
 

Seeker

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well pinks by bd are pretty incredible but they are also faked alot too
 

metsfan4life

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lolz yall and your clomid and hcg size talks. i thought dribbles were better. dang it, ive been lied to when i was told "i love the small load"
 

Texan69

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I react poorly to orals, I do react though
40mg of dbol I only gained 6 pounds however my strength, recovery and intensity did go up fairly well.
 

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