Voyagersixone
Senior Member
- Joined
- Dec 6, 2019
- Messages
- 1,988
- Reaction score
- 1,007
- Points
- 113
Hi
Throwing out an abstract question here:
Could a potential effect of long-term stress (either lifestyle-related or due to an illness such as anxiety) be the resistance to adrenaline/epinephrine in stimulating lipolysis?
It may be a long shot - but curious to see what’s out there. I’ve seen studies regarding the long term effects of cortisol (on behalf of stress) and its contribution to the obese, but nothing specific to adrenaline.
Elaborating a bit - in the body’s effort to maintain homeostasis, it adapts in a number of ways. Insulin resistance is an example. If the “fight or flight” mechanism is in a constant state of engagement, doesn’t it make sense that fat would eventually become resistant to the constant adrenaline onslaught? And if so, wouldn’t that make drugs like ephedrine (that stimulate adrenaline) less effective?
or I could be nuts. Just an idea - that I can’t seem to find a factual yes or no on yet. Would love the discussion.
Throwing out an abstract question here:
Could a potential effect of long-term stress (either lifestyle-related or due to an illness such as anxiety) be the resistance to adrenaline/epinephrine in stimulating lipolysis?
It may be a long shot - but curious to see what’s out there. I’ve seen studies regarding the long term effects of cortisol (on behalf of stress) and its contribution to the obese, but nothing specific to adrenaline.
Elaborating a bit - in the body’s effort to maintain homeostasis, it adapts in a number of ways. Insulin resistance is an example. If the “fight or flight” mechanism is in a constant state of engagement, doesn’t it make sense that fat would eventually become resistant to the constant adrenaline onslaught? And if so, wouldn’t that make drugs like ephedrine (that stimulate adrenaline) less effective?
or I could be nuts. Just an idea - that I can’t seem to find a factual yes or no on yet. Would love the discussion.
Last edited: