Z
Zeek
Guest
and most important why would anyone want to use this during pct, a time when you need your igf levels at least to normal levels to retain as much muscle as possible while wiaiting for natural levels to kick back in hormone wise
Keep in mind that clomid does not impact igf level.s .Nolvadex is what is called a selective estrogen agonist. This means that to some tissues it appears to be an estrogen. At other places breast tissue is another example, tamoxifen will bond to the estrogen receptor without actually flippin the on switch. This stops estrogenic acitivity at that site regardless of free estrogen levels becuase the receptor is road-blocked . The reason nolvadex is supposed to lower igf levels is becuase it appears to your liver as an estrogen like metabolite thereby bonding to and acitivating E receptors in you liver. Estrogen is a signal in your liver to lower the production of igf-1.
Keep in mind that clomid does not impact igf level.s .Nolvadex is what is called a selective estrogen agonist. This means that to some tissues it appears to be an estrogen. At other places breast tissue is another example, tamoxifen will bond to the estrogen receptor without actually flippin the on switch. This stops estrogenic acitivity at that site regardless of free estrogen levels becuase the receptor is road-blocked . The reason nolvadex is supposed to lower igf levels is becuase it appears to your liver as an estrogen like metabolite thereby bonding to and acitivating E receptors in you liver. Estrogen is a signal in your liver to lower the production of igf-1.