Results 1 to 11 of 11
  1. #1
    Senior Member getgains's Avatar
    Join Date
    Dec 2012
    Location
    ontario
    Posts
    186
    Thanks
    0
    Thanked 2 Times in 2 Posts

    acvr2b any thoughts

    I came across quite a bit of these from what i have read its amazing anyone have any thoughts on this?

  2. #2
    Elite Christosterone's Avatar
    Join Date
    Oct 2012
    Location
    Texas
    Posts
    1,026
    Thanks
    16
    Thanked 16 Times in 16 Posts

    Re: acvr2b any thoughts

    How many grams do ou gave, what were you planning to do per week
    All posts are for entertainment purposes only

  3. #3
    Elite Christosterone's Avatar
    Join Date
    Oct 2012
    Location
    Texas
    Posts
    1,026
    Thanks
    16
    Thanked 16 Times in 16 Posts

    Re: acvr2b any thoughts

    You have****
    All posts are for entertainment purposes only

  4. #4
    Senior Member getgains's Avatar
    Join Date
    Dec 2012
    Location
    ontario
    Posts
    186
    Thanks
    0
    Thanked 2 Times in 2 Posts

    Re: acvr2b any thoughts

    I'm going to try 100 mcg ed for the next 6 weeks before I go back to test and dbol

  5. #5
    Elite 63Vette's Avatar
    Join Date
    Jun 2012
    Posts
    2,256
    Thanks
    6
    Thanked 28 Times in 12 Posts

    Re: acvr2b any thoughts

    ACE-031: I would love to see a log on this. I'm not sure I want to be the guinea pig myself.

    From what I can tell it is excellent for strength gains with a few sides. The second phase of trials was halted due to minor safety concerns (which could have more serious ramifications).

    Here is the most current information I could find on the study: http://clinicaltrials.gov/ct2/show/NCT01099761

    The best explanation I have found for mechanism of action is this:

    MECHANISM OF ACTION

    Muscle growth is regulated by proteins in the TGF-β protein superfamily that serve as “on” or “off” switches for muscle production. Several molecules, including myostatin (GDF8), interact with the ActRIIB receptor and send an “off” signal to stop muscle growth. When these “off” switch molecules are absent or blocked, muscle mass increases dramatically. There is substantial evidence of the role of GDF8 and related molecules in muscle growth. Cattle, rodents, dogs, and even humans with naturally occurring mutations in GDF8 have markedly increased musculature and strength.


    ACE-031 is a recombinant fusion protein consisting of the extracellular portion of the human ActRIIB receptor linked to a portion of a human antibody. This creates a freely circulating, decoy version of ActRIIB which interferes with myostatin and other related members of the TGF-β superfamily that normally limit the growth and regeneration of muscle.

    In animal models of muscle disease, including a model of DMD, the mdx mouse, treatment with ACE-031 or a rodent version of the molecule increased skeletal muscle mass and strength. In Phase 1 studies in healthy postmenopausal women, treatment with ACE-031 resulted in dose-dependent increases in lean mass. These results suggest that ACE-031 may have potential to increase muscle mass and improve strength and function in human muscle diseases such as DMD.



    Respect,
    Vette
    Hung like Einstein and Smart as a Mule.

  6. #6
    Senior Member getgains's Avatar
    Join Date
    Dec 2012
    Location
    ontario
    Posts
    186
    Thanks
    0
    Thanked 2 Times in 2 Posts

    Re: acvr2b any thoughts

    after looking at all the diffrent peptides i could find i made my decision on this one i was thinking a low does i.e 100 mcg ed would be about right for me im off cycle right now and having a hard time gaining anything i wont be back on cycle for at least 6 weeks if i will start a log on it. once i get going i might stack with hgh-frag as well

  7. #7
    Elite 63Vette's Avatar
    Join Date
    Jun 2012
    Posts
    2,256
    Thanks
    6
    Thanked 28 Times in 12 Posts

    Re: acvr2b any thoughts

    You know if this adds substantially to the number of muscle fibers/receptors as it did in trials (at a pretty high dose) the synergy with aas would be phenomenal. Blowing past natural genetic limits would be, at minimum, expected.

    I wish they would continue trials on this. They stopped because of some participants experienced minor nosebleeds, gum bleeds and/or dilation of blood vessels in the skin. I think they were concerned that micro vessels in other organs could experience dilation to the point of rupture. otherwise, I cannot see them stopping trials for an occasional nose bleed or gum bleed.

    Either way, please keep us informed brother. \


    Respect,
    Vette
    Hung like Einstein and Smart as a Mule.

  8. #8
    Senior Member getgains's Avatar
    Join Date
    Dec 2012
    Location
    ontario
    Posts
    186
    Thanks
    0
    Thanked 2 Times in 2 Posts

    Re: acvr2b any thoughts

    maybe you right if i stack this with my next cycle i might have huge gains im looking to get to 325-350 i read that study too thats why i was thinking of using it alone

  9. #9
    Elite 63Vette's Avatar
    Join Date
    Jun 2012
    Posts
    2,256
    Thanks
    6
    Thanked 28 Times in 12 Posts

    Re: acvr2b any thoughts

    Originally Posted by getgains View Post
    maybe you right if i stack this with my next cycle i might have huge gains im looking to get to 325-350 i read that study too thats why i was thinking of using it alone
    It sounds like it would be great in PCT or between cycles to help hold gains but it was stopped for safety reasons... now, realize the actual clinical trials were for kids with MD as young as 4 years old.

    Yes, if you are producing more receptors and muscle fibers and applying an aas to that- seems like it would enhance growth big time.

    Is your supply unlimited? Is it expensive?

    Just be careful - you are in new territory brother.

    Respect,
    Vette
    Hung like Einstein and Smart as a Mule.

  10. #10
    Senior Member getgains's Avatar
    Join Date
    Dec 2012
    Location
    ontario
    Posts
    186
    Thanks
    0
    Thanked 2 Times in 2 Posts

    Re: acvr2b any thoughts

    i have enough to run for a few months but like you said the potential for growth is amazing but sides are really unknown but as they say fortune favors the brave ill let you know how it goes thanks

  11. #11
    Elite gymrat827's Avatar
    Join Date
    Dec 2011
    Location
    shy town
    Posts
    6,762
    Thanks
    201
    Thanked 1,795 Times in 1,266 Posts

    Re: acvr2b any thoughts

    igf/mgf combo will take you way past natty growth. I like all pep's but these ones that are too good to be true never work as said. but if your going to take the plunge please let us all know how it goes.

    id love to see you get good results.


    GL

Similar Threads

  1. New Cycle, Any Thoughts?
    By JakdJay in forum Anabolic Steroid Cycle Discussion
    Replies: 8
    Last Post: 02-22-2015, 04:40 PM
  2. Jeff Daniels speech...Any thoughts on this?...
    By Popeye in forum General Chat & Conversation
    Replies: 9
    Last Post: 11-14-2013, 03:32 AM
  3. Time to teach about ACVR2B!
    By hulksmash in forum Peptides And Growth Hormone
    Replies: 4
    Last Post: 04-15-2013, 10:37 AM
  4. Ok confused,any thoughts
    By Bullseye Forever in forum Anabolic Steroid Cycle Discussion
    Replies: 18
    Last Post: 09-04-2012, 10:29 PM
  5. New cycle,starting in either August or September....any thoughts?
    By Bullseye Forever in forum Anabolic Steroid Cycle Discussion
    Replies: 14
    Last Post: 06-28-2012, 07:58 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •