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  1. #1
    Elite 63Vette's Avatar
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    Why we should be using exemestane

    STOLEN from AC on another site but I couldn't have put it together any better:

    Why we Should all use Exemestane.

    Okay members, here is a piece of information i would like all of to know, this info is of importance as I for one still love my aridmidex and also my exemestane, i never do a cycle without exemestane, so if you are looking to control estrogen and keep it at bay, than i would suggest you experiment with what works for you, some will like adex and some say it makes them feel like shit, on the other hand exemestane is know to make one feel awake and great while on as opposed to adex. UR


    Aromasin (exemestane) is a steroid-al AI - an irreversible aromatase inhibitor ... great for controlling estrogen "during cycle" and "PCT" ...

    But, what else does it do ???
    Good reading....

    ABSTRACT FROM JOURNAL OF CLINICAL ENDOCRONOLOGY AND METABOLISM

    Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose.

    RESULTS :

    The 25- and 50-mg doses of daily exemestane had comparable effects in suppressing circulating estrogen concentrations, with 38 24% (mean SD; P = 0.002 vs. baseline) and 32 29% (P = 0.008) decreases in estradiol concentrations, 71 12% (P < 0.0001) and 74 12% (P < 0.0001) decreases in estrone concentrations, and 45 27% (P = 0.004) and 51 20% (P = 0.02)

    BUT THERE'S MORE

    There was an increase in circulating testosterone concentrations after both 25 mg (60 58%; P = 0.001) and 50 mg (56 48%; P = 0.003) exemestane. Androstenedione concentrations were increased as well after 25 mg (32 36%; P = 0.004) and 50 mg (47 59%; P = 0.052) exemestane, respectively (Fig. 1Go and Table 2Go).

    SHBG concentrations were decreased by 21 7% (P = 0.0003) and 19 39% (P = 0.18) at 25 and 50 mg exemestane, respectively.

    Free testosterone concentrations were increased by 117 74% (P = 0.0001) and 154 95% (P < 0.0001) at both doses, due to the decrease in SHBG and the increase in total testosterone.

    THE ICING ON THE CAKE !

    There were no changes in circulating serum triglycerides, cholesterol, or LDL or HDL cholesterol concentrations with either dose of exemestane.


    Many Thanks to AC on AB for allowing me to cut and paste his cut and paste!

    Much Respect,
    Vette
    Hung like Einstein and Smart as a Mule.

  2. #2
    Senior Moderator NbleSavage's Avatar
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    Re: Why we should be using exemestane

    Great add, Vette.

    I'm a fan of the 'stane.

  3. #3
    Elite TheLupinator's Avatar
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    Re: Why we should be using exemestane

    Def my favorite AI, and great info here too.
    I <3 My Source

  4. #4
    Elite Tren4Life's Avatar
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    Re: Why we should be using exemestane

    Thanks for looking out for me Vette. You a great brother.
    traps are the new abs.

  5. #5
    Elite Jada's Avatar
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    Re: Why we should be using exemestane

    Love my stane works just fine! Thanks for the post 63
    Eating ass is anabolic. .. Stick your tongue in and hold it there for 20 seconds! Wise words from
    TRODIZZLE

  6. #6
    Georgia
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    Re: Why we should be using exemestane

    I thought it was crap...only because I had gotten it from Pinnacle. And the clomid too. I was like...why won't you work!? Why won't my load explode out the barrel?! Then...I looked at my huge painful shoulders and shrunken balls and puffy nips...and realized....I was punk'd by Zeek into buying this crap.

    Anyways yeah I agree with you good stuff Vette.

    Respectfully scammed,
    Georgia

  7. #7
    Elite 63Vette's Avatar
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    Re: Why we should be using exemestane

    Originally Posted by Georgia View Post
    I thought it was crap...only because I had gotten it from Pinnacle. And the clomid too. I was like...why won't you work!? Why won't my load explode out the barrel?! Then...I looked at my huge painful shoulders and shrunken balls and puffy nips...and realized....I was punk'd by Zeek into buying this crap.

    Anyways yeah I agree with you good stuff Vette.

    Respectfully scammed,
    Georgia

    Brother, I have used manpower exclusively for my exemastane and cabergoline for a few years (since he started). Forget those other places and go with MP for your stane. Your AI has a lot to do with how you feel on cycle and MP delivers the best quality time after time after time.

    Much Respect,
    Vette
    Hung like Einstein and Smart as a Mule.

  8. #8
    Georgia
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    Re: Why we should be using exemestane

    Originally Posted by 63Vette View Post
    Brother, I have used manpower exclusively for my exemastane and cabergoline for a few years (since he started). Forget those other places and go with MP for your stane. Your AI has a lot to do with how you feel on cycle and MP delivers the best quality time after time after time.

    Much Respect,
    Vette
    Thanks Vette. Will check them out for sure

  9. #9
    Banned Tilltheend's Avatar
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    Re: Why we should be using exemestane

    I use Aromasin myself.

  10. #10
    Elite FreeBirdSam's Avatar
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    Re: Why we should be using exemestane

    stane reversed my gyno from dbol. made me feel healthier, my lipids improved slightly, only AI I will use from now on thanks to whoever in the chatbox told me to try it

  11. #11
    Elite PFM's Avatar
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    Re: Why we should be using exemestane

    I am curious how many guys run 12.5 and how many 25mgs Stane?
    Thugs
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  12. #12
    Elite 63Vette's Avatar
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    Re: Why we should be using exemestane

    I'm a 12.5 eod guy..... doesn't matter how much test or test derivatives I am running that for whatever reason is my dose. I feel great, have full sexual function, and can pull the trigger. I think the dose depends of how readily test aromatizes in each person's system and how susceptible they are to estro related problems.

    Caber for the 19 nors and aromasine for test and test derivatives that aromatize. The two biggest improvements in cycles since I have been around the game are caber and stane IMO.


    Much Respect,
    Vette
    Hung like Einstein and Smart as a Mule.

  13. #13
    Elite don draco's Avatar
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    Re: Why we should be using exemestane

    Thanks Vette. Great post as always. I was trying to decide between aromasin & arimidex for my first cycle.. and now I think I have my answer. Cheers

  14. #14
    Senior Member regular's Avatar
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    Re: Why we should be using exemestane

    Originally Posted by Tilltheend View Post
    I use Aromasin myself.
    Aromasin is a brand name exemestane. It's the same molecule.

  15. #15
    Elite TheLupinator's Avatar
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    Re: Why we should be using exemestane

    12.5mg ED is perfect for me when running test @350-500/week.

    As a reference point, I'm sensitive to aromatization/estro problems. had pubertal gyno that I can still feel in my right nip and it flared up my first cycle running 600mg/week of test.
    I <3 My Source

  16. #16
    Elite FreeBirdSam's Avatar
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    Re: Why we should be using exemestane

    12.5 EOD guy here. Every day if I'm trying to reverse gyno quickly, although ED dosing crashed my estro last time.

  17. #17
    Elite bubbagump's Avatar
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    Re: Why we should be using exemestane

    Thanks for the post Vette. Always like to read your posts. I have used 12.5 Ed, EOD and 25 Ed trying to lock it in but I can't figure it out. I love exemestane. Been taking 12.5 2days on one day off on trt and noticed today that I was an emotional little bitch and my nips are sore and itchy. Think I'll just go to 25eod.

  18. #18
    Elite GenetixSupreme's Avatar
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    Re: Why we should be using exemestane

    Answered my question... Thanks much Vette!

  19. #19
    Elite AlphaD's Avatar
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    Re: Why we should be using exemestane

    Thanks Vette for info. It is the AI I had long decided to use with this run. I am going to go 12.5 eod, to get a gauge on whats is what ........Great post.

  20. #20
    Elite Bullseye Forever's Avatar
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    Re: Why we should be using exemestane

    I love it,always works for me

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