- Joined
- Feb 17, 2013
- Messages
- 925
- Reaction score
- 315
- Points
- 63
Grapefruit juice inhibits the cytochrome P450 CYP3A4 enzyme, which can affect the metabolism/absorption of a variety of drugs, increasing their bioavailability. CYP3A4 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
Some links to more info on GFJ:
http://www.ncbi.nlm.nih.gov/pubmed/17112309
http://www.ncbi.nlm.nih.gov/pubmed/9548795