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  1. #1
    Elite hulksmash's Avatar
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    DNP-The Science and best way to use it

    Infantry got me wantin to post about DNP with his post

    Originally Posted by Infantry87 View Post
    Never heard of dnp making you hold water
    Believe it or not a lot of people talk about dnp and holding water

    A lot of people use it wrong too, not knowing the science behind it..

    DNPs lipolytic effect is a result of poisoning-

    yea, for the most part DNP will take fat off of ya no matter what you eat

    but if we're talkin contest prep you can notice the water and the LACK of glute striations=losing to the guy(s) who dialed in right

    覧覧覧覧覧覧覧覧

    HERE'S HOW/WHY YOU RUN DNP RIGHT

    DNP= uncoupling (ie preventing) oxidative phosphorylation

    Uncoupling oxidative phosphorylation= Stopping the oxidation (ie breakdown) of nutrients (eg glycogen or fatty acids) to CREATE ATP

    ATP Creation= Glucose (glycogen is the main) → glycolysis → pyruvate (pyruvic acid) → Acetyl coenzyme A+H2O* → CO2+Krebs Cycle → NADH+FADH2 → electrons from NADH+FADH2 → oxidative phosphorylation → ATP!

    NO MORE GLYCOGEN=BODY USES ADIPOSE (FAT LOSS) TO CREATE ATP!

    ATP Creation on DNP AFTER NO GLYCOGEN (thus fat loss!): No glucose left to make NADH and FADH2=body turns to fatty acids (lipolysis)

    Adipose tissue (triglycerides) → Free fatty acids → Fatty acids+Carnitine palmitoyl → Fatty acyl-carnitine+Coenzyme A → Beta Oxidation → Acetyl Coenzyme A +H2O* → CO2+Krebs cycle→ NADH+FADH2 → electrons from NADH+FADH2 → oxidative phosphorylation → ATP!


    What does this mean?

    - Begin DNP with a very low carb/keto diet+high rep lifting to deplete ALL glucose

    -glucose is gone; DNP causes body to use adipose tissue to make ATP

    -reintroduce carbs (ESPECIALLY SIMPLE CARBS-less steps to glucose conversion thus more uncoupling), taking full advantage of the uncoupling (ie huge temp increase+fat loss)

    -keep fat low, 60-70% carbs (lotta fruit), rest protein

    -you will more than likely look flat; DNP will make the body eat up glucose+fatty acids like candy just to make ATP

    -TAKE B COMPLEX+plenty of water...AGAIN-B COMPLEX! The B vitamins are used in EVERY step (eg b5 for CoA, b2 for beta oxidation, etc) and you also piss them out (which is a risk if on DNP due to extra water intake)

    * I made sure to note that H2O was a product with Acetyl Coenzyme A because that could be the step where people start to hold water

    Anywho hope ya enjoyed! If you want to get nerdier with more questions, lets do it lol

  2. #2
    Elite Infantry87's Avatar
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    Re: DNP-The Science and best way to use it

    Your welcome lol. Nice post bro
    The test of a man's character is what it takes to stop him.

  3. #3
    Elite PillarofBalance's Avatar
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    Re: DNP-The Science and best way to use it

    What does this mean?

    - Begin DNP with a very low carb/keto diet+high rep lifting to deplete ALL glucose

    -glucose is gone; DNP causes body to use adipose tissue to make ATP

    -reintroduce carbs (ESPECIALLY SIMPLE CARBS-less steps to glucose conversion thus more uncoupling), taking full advantage of the uncoupling (ie huge temp increase+fat loss)

    -keep fat low, 60-70% carbs (lotta fruit), rest protein

    -you will more than likely look flat; DNP will make the body eat up glucose+fatty acids like candy just to make ATP
    Glycogen not glucose but we get your point.

    Your info is incorrect in this section though. You are suggesting that carbohydrates make DNP work when they do not. The temp increase has no direct correlation to fat loss. That is the same as saying that gyno means that you're synthesizing proteins at crazy rates from test injections.

    Rather than feed you cause you're a nerd and I get all hot and bothered when you talk like this I'll just offer a hint. Go back to the books and look closer at where the ATP is going. What actually is generating the heat sensation?

    I'd also add under the how to run DNP section - Add ephedrine. DNP should always be ran with ephedrine.
    "Overzealous dosing" -Jin

    Rest in Peace Robot Lord. First round of Natty Boh is on me when I make it up there with you brother.

  4. #4
    Elite TheLupinator's Avatar
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    Re: DNP-The Science and best way to use it

    Ya....I'm still confused. As I *kinda* understand it DNP prevents ATP from being produced by taking the energy from the oxidation (breakdown) of food and releasing it as heat? Basically makes your body inefficient at producing ATP? so you need to oxidize more food to make the same amount of ATP? Regardless if carbs are present?
    I <3 My Source

  5. #5
    Elite hulksmash's Avatar
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    Re: DNP-The Science and best way to use it

    I ran outta time to reply tonight (damnit) But Lupinator-

    DNP prevents ATP production by uncoupling oxidative phosphorylation

    You will STILL make ATP via Substrate level phosphorylation

  6. #6
    Elite hulksmash's Avatar
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    Re: DNP-The Science and best way to use it

    Originally Posted by PillarofBalance View Post
    Glycogen not glucose but we get your point.

    Your info is incorrect in this section though. You are suggesting that carbohydrates make DNP work when they do not. The temp increase has no direct correlation to fat loss. That is the same as saying that gyno means that you're synthesizing proteins at crazy rates from test injections.

    Rather than feed you cause you're a nerd and I get all hot and bothered when you talk like this I'll just offer a hint. Go back to the books and look closer at where the ATP is going. What actually is generating the heat sensation?

    I'd also add under the how to run DNP section - Add ephedrine. DNP should always be ran with ephedrine.

    I had written what caused the body temp increase but must've deleted it-basically heat is the product of the energy built up from the proton motive force-

    Since DNP allows protons to permeate the cell membrane, protons bypass ATP Synthase and thus ADP doesn't get its oxidative phosphorylation

    Ill post more at lunch

  7. #7
    Elite Bro Bundy's Avatar
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    Re: DNP-The Science and best way to use it

    whats with all these big fancy nerd words...its not that complicated eat clean take 500mg of dnp drop body fat..no need to get all technical on us

  8. #8
    Elite hulksmash's Avatar
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    Re: DNP-The Science and best way to use it

    Bundy some people want to know the HOW of some things

  9. #9
    Elite Bro Bundy's Avatar
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    Re: DNP-The Science and best way to use it

    how long did u run dnp and what dose?

  10. #10
    Elite hulksmash's Avatar
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    Re: DNP-The Science and best way to use it

    Originally Posted by PillarofBalance View Post
    Glycogen not glucose but we get your point.

    Your info is incorrect in this section though. You are suggesting that carbohydrates make DNP work when they do not. The temp increase has no direct correlation to fat loss. That is the same as saying that gyno means that you're synthesizing proteins at crazy rates from test injections.
    I wasn't trying to say carbs make the DNP work, rather it looks like a person would get the most benefit from allowing DNP to deplete glycogen stores with low carb at keto at first make the body switch to Lipolysis

    Lipolysis will occur because it's gotta make Acetyl cao and NADH without glycogen to start the Krebs cycle and get to oxidative phosphorylation

    The simple carbs are thrown in to keep fueling glycolysis-this is the process your body will use to create ATP through substrate-level phosphorylation, since it can't use oxidative phosphorylation to make ATP

    And yes, body temp isn't a correlation to fat loss-it does indicate that uncoupling is happening so do what you can to make the body switch to fatty acids

  11. #11
    Elite PillarofBalance's Avatar
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    Re: DNP-The Science and best way to use it

    Originally Posted by hulksmash View Post
    I wasn't trying to say carbs make the DNP work, rather it looks like a person would get the most benefit from allowing DNP to deplete glycogen stores with low carb at keto at first make the body switch to Lipolysis

    Lipolysis will occur because it's gotta make Acetyl cao and NADH without glycogen to start the Krebs cycle and get to oxidative phosphorylation

    The simple carbs are thrown in to keep fueling glycolysis-this is the process your body will use to create ATP through substrate-level phosphorylation, since it can't use oxidative phosphorylation to make ATP

    And yes, body temp isn't a correlation to fat loss-it does indicate that uncoupling is happening so do what you can to make the body switch to fatty acids

    See the bold ^^^^

    What I'm saying is that it absolutely is NOT necessary to have any carbohydrates at all. They do not make DNP more effective. Doing what you can to make the body switch to fatty acids is done by sticking to a ketogenic diet and adding ephedrine.
    "Overzealous dosing" -Jin

    Rest in Peace Robot Lord. First round of Natty Boh is on me when I make it up there with you brother.

  12. #12
    Elite hulksmash's Avatar
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    Re: DNP-The Science and best way to use it

    Originally Posted by PillarofBalance View Post
    See the bold ^^^^

    What I'm saying is that it absolutely is NOT necessary to have any carbohydrates at all. They do not make DNP more effective. Doing what you can to make the body switch to fatty acids is done by sticking to a ketogenic diet and adding ephedrine.
    I see what you're sayin and it's right

    But for those still wanting to lift its gonna be smart to use some simple carbs for their workouts

    If you REALLY wanted to shed fat (without care for health) you'd do keto+DNP+Gh+insulin+Ghrelin mimetics+amphetamines+formoterol+gear+t3

    Holy shit would a person drop fat LOL everyone one of those things induce lipolysis

  13. #13
    Elite PillarofBalance's Avatar
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    Re: DNP-The Science and best way to use it

    Originally Posted by hulksmash View Post
    I see what you're sayin and it's right

    But for those still wanting to lift its gonna be smart to use some simple carbs for their workouts

    If you REALLY wanted to shed fat (without care for health) you'd do keto+DNP+Gh+insulin+Ghrelin mimetics+amphetamines+formoterol+gear+t3

    Holy shit would a person drop fat LOL everyone one of those things induce lipolysis
    Right on... Fruit is usually recommended before and during training.
    "Overzealous dosing" -Jin

    Rest in Peace Robot Lord. First round of Natty Boh is on me when I make it up there with you brother.

  14. #14
    Elite hulksmash's Avatar
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    Re: DNP-The Science and best way to use it

    Originally Posted by PillarofBalance View Post
    Right on... Fruit is usually recommended before and during training.
    And theyre the better choice when all you got is glycolysis to make ATP

    That way u can get quicker back to a keto/depleted glycogen state

  15. #15
    Elite PillarofBalance's Avatar
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    Re: DNP-The Science and best way to use it

    Originally Posted by hulksmash View Post
    And theyre the better choice when all you got is glycolysis to make ATP

    That way u can get quicker back to a keto/depleted glycogen state
    Good point. Lets add some metformin to your stack above.
    "Overzealous dosing" -Jin

    Rest in Peace Robot Lord. First round of Natty Boh is on me when I make it up there with you brother.

  16. #16
    Elite hulksmash's Avatar
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    Re: DNP-The Science and best way to use it

    Originally Posted by PillarofBalance View Post
    Good point. Lets add some metformin to your stack above.
    That's it I got a boner

    I say we kidnap MW and run that shit on him LOL dat dere experimentation

  17. #17
    Georgia
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    Re: DNP-The Science and best way to use it

    That stack should be called the 'How to Look Cut For Your Funeral Stack'

  18. #18
    Elite PillarofBalance's Avatar
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    Re: DNP-The Science and best way to use it

    Originally Posted by Georgia View Post
    That stack should be called the 'How to Look Cut For Your Funeral Stack'
    Most shredded corpse ever...

    "Overzealous dosing" -Jin

    Rest in Peace Robot Lord. First round of Natty Boh is on me when I make it up there with you brother.

  19. #19
    Elite hulksmash's Avatar
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    Re: DNP-The Science and best way to use it

    Originally Posted by Georgia View Post
    That stack should be called the 'How to Look Cut For Your Funeral Stack'
    LOL

    What's sad is pro's actually run that now that I think about it

  20. #20
    Elite hulksmash's Avatar
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    Re: DNP-The Science and best way to use it

    Originally Posted by TheLupinator View Post
    Ya....I'm still confused. As I *kinda* understand it DNP prevents ATP from being produced by taking the energy from the oxidation (breakdown) of food and releasing it as heat? Basically makes your body inefficient at producing ATP? so you need to oxidize more food to make the same amount of ATP? Regardless if carbs are present?
    Also wanted to tell you-

    Do NOT worry about the word "oxidation"

    The way youre using it is not how dnp or atp production works-O2 and phosphorous is donated to begin atp creation..the oxygen molecule=source of "oxidative, oxidize" terms

    You do not need more food on dnp to make atp

    However, you need simple carbs if youre gonna lift because youre making atp ONLY through glycolysis while on DNP (via substrate phosphorylation)

    Other wise stick to keto to induce lipolysis

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