Bloods concerning estradiol

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So full trough bloods finally came back. My estradiol is sky high. I know AIs are typically more last resort, but this number also kind of rocked me. I will say the symptoms are there the first month and half sex drive was of the charts and everything was fine, later libido dropped off and some ED issues started.

Would it be better to lower dose and spread it out to prevent spikes or look more into an AI. Since this is trough I'm probably 1100-1300 and 100+ peak.
 

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snake

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What are you taking and dosage. You gotta come with all the info if you want someone to help.
 
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What are you taking and dosage. You gotta come with all the info if you want someone to help.
My bad, was a bit of a panic post pretty new to the arena.

160 mg test c twice a week. I will concede im overweight at the moment, which is likely causing most of the elevated estra.
 

snake

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160 2x/wk= 320 mg per week?

Something seems fuuked up. At 320 mg/wk on cyp your TT should be 1400 ng dl. Since cyp has a half life of about 6-7 days, you really don't see a trough pinning 2x/wk. No reason your TT should be in upper range and your Free that high.

But that wasn't your question. That E2 has to come down. Your BF doesn't help but it should be that high.

Your Test cyp scripted?
 
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160 2x/wk= 320 mg per week?

Something seems fuuked up. At 320 mg/wk on cyp your TT should be 1400 mg dl. Since cyp has a half life of about 6-7 days, you really don't see a troughs pinning 2x/wk. No reason your TT should be in upper range and your Free that high.

But that wasn't your question. That E2 has to come down. Your BF doesn't help but it should be that high.

Your Test cyp scripted?
And this is where my inexperience really shows. 80 mg 2x total 160 mg a week. Sorry for all the confusion and thanks for taking time to look at this stuff. It's scripted via Petermd, filled at a compounding pharm in fl
 

snake

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And this is where my inexperience really shows. 80 mg 2x total 160 mg a week. Sorry for all the confusion and thanks for taking time to look at this stuff
It's ok brother, we're all in this together. Then the TT is good and he happy with the Free.

You do not want to go start and AI on a TRT dose. TRT, assuming that's what you're doing is a life long commitment. You don't want to committed to an AI.
 
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It's ok brother, we're all in this together. Then the TT is good and he happy with the Free.

You do not want to go start and AI on a TRT dose. TRT, assuming that's what you're doing is a life long commitment. You don't want to committed to an AI.
Ya it's trt, if troughs aren't really there with 2x a week I'll ask about lowering the dose. There was a window about week 2-6 I felt amazing maybe I had hit a sweet spot and kept increasing T/E to much due to the dosage
 

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My bad, was a bit of a panic post pretty new to the arena.

160 mg test c twice a week. I will concede im overweight at the moment, which is likely causing most of the elevated estra.

You're correct, excess fat tissue will increase the aromatase enzyme, thus increasing the conversion to estradiol. Another reason to get lean.

Try daily 20 mg micro doses of Testosterone using insulin needles. It should help keep your estradiol at a more acceptable level.
 

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Quick lesson in half lives, maximum saturation is it about five half-life. Therefore with a 6-7 day half life you will peak out at about week 4-5. So what you're saying makes sense.

Most Dr would cut your dose with the E2. I'm at a bit of a loss honestly. Here's what I would do. Take an AI to stop the bleeding for now. Drop the dose to say 125 mg a week and pin once.

The hard part is you want to know where you're at without the AI. Give it about a month on the AI and retest.

This isn't an easy one to fix but let's at least get your dick working before that fuuks up your head too.
 

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You're correct, excess fat tissue will increase the aromatase enzyme, thus increasing the conversion to estradiol. Another reason to get lean.

Try daily 20 mg micro doses of Testosterone using insulin needles. It should help keep your estradiol at a more acceptable level.
Definitely an option CJ.

Just wish I could get him to s normal 1 pin a week with normal numbers.

Poor dude is not doing anything crazy, just TRT and shouldn't have to deal with this.

Do cut the fat OP before you have other issues.
 
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Ya, I used to lift regularly the fat came with the low t over years, and was one of the factors that caused me to test to begin with. Immediate priority is back to shape, I will say my energy is still ok, was better at the start, but I no longer have to nap for 3/4 hours. Been consistently following 5/3/1 as a beginner again.
 

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Definitely an option CJ.

Just wish I could get him to s normal 1 pin a week with normal numbers.

Poor dude is not doing anything crazy, just TRT and shouldn't have to deal with this.

Do cut the fat OP before you have other issues.

I feel his pain. I can't run simple TRT once per week, either. I have to do 2x or greater, or I run into skin issues.

Once I figured that out, things got much better.
 

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Ya, I used to lift regularly the fat came with the low t over years, and was one of the factors that caused me to test to begin with. Immediate priority is back to shape, I will say my energy is still ok, was better at the start, but I no longer have to nap for 3/4 hours. Been consistently following 5/3/1 as a beginner again.

Just remember, lifting is to build or retain muscle, it is NOT to lose fat. You lose fat by consistently being in a reasonable caloric deficit and eating healthy foods, proper protein, intelligent training, over time.
 
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Just remember, lifting is to build or retain muscle, it is NOT to lose fat. You lose fat by consistently being in a reasonable caloric deficit and eating healthy foods, proper protein, intelligent training, over time.
Will, do. 5/3/1 is typically at least 30 mins of something outside of lifting, I can up that and dial diet in more. I want to avoid an AI if I can based on everything I read. I'll see if the doc is ok with 20 mg ED insulin. I don't see why they wouldn't be.
 

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Will, do. 5/3/1 is typically at least 30 mins of something outside of lifting, I can up that and dial diet in more. I want to avoid an AI if I can based on everything I read. I'll see if the doc is ok with 20 mg ED insulin. I don't see why they wouldn't be.

Daily injections will lower the spike of the testosterone, while also raising the troughs. It's more of a smooth ride, and the lower peak should lower the peak of the estradiol conversion. Many do this, it's perfectly reasonable for TRT.

Going to more frequent injections markedly lessens the unwanted side effects for many.

Do you self inject at home? If so, you can just order your own needles online. No RX is needed.
 
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Daily injections will lower the spike of the testosterone, while also raising the troughs. It's more of a smooth ride, and the lower peak should lower the peak of the estradiol conversion. Many do this, it's perfectly reasonable for TRT.

Going to more frequent injections markedly lessens the unwanted side effects for many.

Do you self inject at home? If so, you can just order your own needles online. No RX is needed.
Ya I inject at home been doing ventroglute and it goes smooth, but insulin needles likely wouldn't hit deep enough I may order some 30g 1/2" luer locks to keep my pin location. I suppose I could try subq or delts, pretty lean there.

Thank you both for your time. I have an appt tomorrow and I'll draw bloods again 8-12 weeks after the change and repost so it can be seen by any new people like me.
 
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