Dosing

[JoeAdonis]

I’m curious to hear what you all have to say regarding the following. I’ve been off gear for 6 yrs. Going to start again. As you can imagine, my receptors are all clear. Given that fact, I was wondering if it would be beneficial to start my dosages high to take advantage of the receptors being wide open… then taper down later in the cycle. Or, would it be better to start low and increase as the cycle progresses? My rationale is that over the course of a cycle the receptors become saturated… so your body wouldn’t be able to make use of the drug no matter how much you used. Thank you in advance for any input received.

 

[Yano]

downregulation of AR is pretty much considered debunked by several big brains. they dont clog up they dont need to be cleaned out

Downregulation of Androgen Receptors upon Anabolic-Androgenic Steroids: A Cause or a Flawed Hypothesis of the Muscle-Building Plateau?

Researchers and health practitioners seek to understand the upper limit of muscle hypertrophy under different conditions. Although there are models to estimate the muscle-building threshold in drug-free resistance training practitioners, little is known about the population using...

www.mdpi.com

 

[JoeAdonis]

downregulation of AR is pretty much considered debunked by several big brains. they dont clog up they dont need to be cleaned out

Thank you for taking the time to reply. Very interesting read. It’s amazing how much things change regarding this subject matter.

 

[Yano]

Thank you for taking the time to reply. Very interesting read. It’s amazing how much things change regarding this subject matter.

Not every one agrees mind you but its good reading and will lead you to gaining more knowledge before you take the leap back into needle slavery.

 

[JoeAdonis]

Nedd

Not every one agrees mind you but its good reading and will lead you to gaining more knowledge before you take the leap back into needle slavery

Not every one agrees mind you but its good reading and will lead you to gaining more knowledge before you take the leap back into needle slavery.

needle

Not every one agrees mind you but its good reading and will lead you to gaining more knowledge before you take the leap back into needle slavery.

Needle slavery. That’s great. I’m going to start out with superdrol. I used it when it was available legally. Shockingly good results. After, I’ll am thinking about the blend masteron/tren ace/test prop blend. Did really well on that too.

 

[Yano]

Nedd



Needle slavery. That’s great. I’m going to start out with superdrol. I used it when it was available legally. Shockingly good results. After, I’ll am thinking about the blend masteron/tren ace/test prop blend. Did really well on that too.

superdrol ahh the slow fun poison. its good stuff if you can stand the indigestion and heartburn and still manage to choke enough food down to put mass on for sure. after 4 to 6 weeks it always made me feel like death was ready to scoop me up for a last cheeseburger on the ride to hell.

 

[JoeAdonis]

superdrol ahh the slow fun poison. its good stuff if you can stand the indigestion and heartburn and still manage to choke enough food down to put mass on for sure. after 4 to 6 weeks it always made me feel like death was ready to scoop me up for a last cheeseburger on the ride to hell.

I tolerated it well. Man it worked for me. It alone worked as well as any combo of other stuff I did.

 

[CJ]

Receptors clear? Wide open? Saturated?

Wow, that's a lot of bro science all at once!!!

That's not how it works at all.

Androgen receptors don't up or down regulate, but your body will make more or less of them depending upon how much androgens are in circulation.

Whereas you haven't used gear in awhile, you have less receptors than you would if you were blasting for a decade straight.

So extra drugs is a complete waste for you, use a minimal effective dose, only add as needed, which will NOT be this run.

Oh, and receptors don't become "saturated". Androgens bind to the androgen receptors, do their signaling, then they release back into circulation.

 

[Wizbang]

Receptors clear? Wide open? Saturated?

Wow, that's a lot of bro science all at once!!!

That's not how it works at all.

Androgen receptors don't up or down regulate, but your body will make more or less of them depending upon how much androgens are in circulation.

Whereas you haven't used gear in awhile, you have less receptors than you would if you were blasting for a decade straight.

So extra drugs is a complete waste for you, use a minimal effective dose, only add as needed, which will NOT be this run.

Oh, and receptors don't become "saturated". Androgens bind to the androgen receptors, do their signaling, then they release back into circulation.

 

[CJ]

Thank you for taking the time to reply. Very interesting read. It’s amazing how much things change regarding this subject matter.

Nothing changed, you just believed things that were untrue.

Side note, Santa isn't real, either.