Life span of "Free" Estrogen after AI usage

[RowdyBrad]

Hope this is the best place for this post.

I have searched Google and forums ahead of time, but for lack of a better term I am hoping to learn more about the "Half Life" or life span of estrogen in the body after a serm and AI have been used.

For example if gyno symptoms come on strong with obviously high e2 and arimidex and Raloxifene are both used to bind the effect and production of estrogen, how long would the high "free estrogen" circulate before lowering on it's own? Hypothetically if 100% were blocked from being produced, how fast does the already produced estrogen lower?

It seems this would be great knowledge for anyone blocking the binding via a serm, otherwise (except for blood testing) how would they know how long to use the serm for? Does it differ greatly between individuals, or is is there a natural correlation or time span like there is with half lives of IV estrogen products (12 hours roughly). If elevated free estrogen is available for under 24 hours or for up to a week, it make a big difference.

I hope my rambling helped the basics of what I am trying ask come through, I don't have the knowledge to probably ask in the best way possible and would appreciate any links, studies, basic info on this. Not so much on blood tests of why not to use an AI or SERM, but more to do with the availability of estrogen after it is blocked.

 

[JeffGoldblumLips]

Also curious about this, I was under impression Arimidex works within the hour and has the most pronounced effect in less than 24 hours. I assumed the conversion by aromatase was an ongoing process so blocking it would decrease circulating levels. However, If E is blocked from being produced as well as binding why does it matter how much is circulating? Wouldn't knowing the half life of the drugs be more pertinent? Sorry if I missed the point completely.

 

[RowdyBrad]

I guess to me it would seemingly matter because if the serm and the AI both have a life span of effectiveness, it would help to know how long you would need to continue the SERM. If you stop prematurely because symptoms go away, or stop the AI prematurely, but estrogen is still circulating at a high range, it could potentially flare up again.

That being said, it could also be entirely a MOOT point and the main reason why it isn't discussed more. Most speak of an AI like Arimidex or anastrozole as a blocker at the point of creation, but does it also kill free estrogen that is circulating? I have read some studies saying and/or when it comes to blocking and also lowering the existing.

My main reason, besides just wanting to know more about estrogen and how it interacts, is because many including myself usually depend more so on just an AI and not the serm, so understanding how long we need to use an AI in relation to not only production but in the length of binding potential seems valuable. If that makes sense at all.