dragon1952
Elite
- Joined
- Feb 20, 2020
- Messages
- 872
- Reaction score
- 640
- Points
- 63
I've been taking pomegranate extract for quite a while as it supposedly is beneficial for the prostate (I have BPH).
I was reviewing the supplements I take recently and found something on pomegranate relating to androgen receptors that concerned me.
Apparently pomegranate extracts/juices are considered antiandrogenic in that they inhibit the binding of hormones (they specifically mention Testosterone and DHT)
to androgen receptors. This is what the medicines prescribed for prostate cancer evidently do also.
The studies I read specifically talk about the androgen receptors in the prostate, but I'm assuming those receptors can't be singled out, so I'm also assuming
that all androgen receptors are being messed with?
So what does that mean if you're taking anabolic steroids? Is there the potential that the binding of those to androgen receptors is also potentially being messed with?
Anybody out there with some scientific knowledge that can explain if this is possible?
Here's a link that is over my head.
www.mdpi.com
And here's a quote "
The medications work by blocking androgens, like testosterone, from binding to androgen receptors, which can slow the growth of prostate cancer cells."
I was reviewing the supplements I take recently and found something on pomegranate relating to androgen receptors that concerned me.
Apparently pomegranate extracts/juices are considered antiandrogenic in that they inhibit the binding of hormones (they specifically mention Testosterone and DHT)
to androgen receptors. This is what the medicines prescribed for prostate cancer evidently do also.
The studies I read specifically talk about the androgen receptors in the prostate, but I'm assuming those receptors can't be singled out, so I'm also assuming
that all androgen receptors are being messed with?
So what does that mean if you're taking anabolic steroids? Is there the potential that the binding of those to androgen receptors is also potentially being messed with?
Anybody out there with some scientific knowledge that can explain if this is possible?
Here's a link that is over my head.

The Androgen Receptor in Prostate Cancer: Effect of Structure, Ligands and Spliced Variants on Therapy
The androgen receptor (AR) plays a predominant role in prostate cancer (PCa) pathology. It consists of an N-terminal domain (NTD), a DNA-binding domain (DBD), a hinge region (HR), and a ligand-binding domain (LBD) that binds androgens, including testosterone (T) and dihydrotestosterone (DHT)...

And here's a quote "
Hormone therapy
“Testosterone suppression with androgen deprivation therapy (ADT) has been the backbone for treatment of prostate cancer,” Dr. Bajaj said. “Currently, we have several second-generation anti-androgens that have better efficacy and potency as well as reduced side effects.”The medications work by blocking androgens, like testosterone, from binding to androgen receptors, which can slow the growth of prostate cancer cells."