Any ladies on this forum? Or anyone who has experience with their girlfriend dealing with this? So, my girlfriend has a severe form of PMS/PMDD. For about 1 week every month, she turns absolutely psychotic. Depressed, irritable, crying, angry, hostile, confused, etc. She gains about 8 pounds of water retention in a day or two, and it leaves just as fast, when menstruation arrives. Her skin becomes darker (like brown) and thicker, and she develops new moles (and her existing moles become darker). This also clears up after the pre-menstrual period; skin goes back to being light/thin and moles fade away, and the water-weight disappears. Any way, she has had this issue for quite a while, and has tried most regular supplements and lifestyle changes. For example, she recently went to see another doctor about this, and when she told him the problems, he told her to "exercise, drink a lot of water and eat veggies like broccoli". She began laughing at the doctor (obviously she has tried all this, and things like Vitamin B6, etc. -- she even tried and SSRI for the depression but it just made it a lot worse). Reading up on it, it does seem like estrogen is the culprit, but how can you control it, for a woman? Does any woman have experiences with taking an aromatase inhibitor (AI) for PMS symptoms? Would it work? Other supplements that might be good for a woman? Like I said, she has tried most of the regular stuff, so I imagine it should be something quite strong to control the symptoms