Great revealing knowledge to plan your DNP runs

I've run low dose cycles for 3-4 weeks. There's no reason you need to keep your cycles short. In the original clinical research, people were kept on DNP for months at a time to over a year, with long-term results. Since the body develops a slight tolerance to DNP, the dose was slowly increased, as needed, to keep weight loss humming along. It doesn't take much DNP to accomplish this. They (Cutting, Tainter, Simkins) usually used 75mg jumps in the clinical research.

The reason shorter cycles are so popular nowadays is because guys typically run high-dose inferno cycles. These necessitate a psychological break, if nothing else, after a couple of weeks. But cycles like this are a poor way to run it, IMO, especially since it's much more dangerous. I've always espoused longer, low-dose cycles, for as long as you need to reach your goals.

Even at lower dosages, you might choose to use DNP cyclically. You might discontinue use every few weeks for a psychological break or maybe as part of an anabolic phase in which you focus on building muscle, like with the UD2.0. I saw that XxCrisisxX likes to run it this way. Whatever the reason, you can start back up on the DNP as soon as you want to. The only reason I'd see someone waiting is if he wanted to ration his DNP, resuming use only after his sensitivity to the drug had been reestablished. In his extensive 1937 research, Simkins said "Tolerance to the drug is established rapidly, so that to produce a consistent loss of weight the dosage must gradually be raised. On the other hand, the acquired tolerance is rapidly lost if the drug is discontinued for as short a period as two weeks. The dinitrophenol may then be resumed at a lower dosage level with its original effect on the patient. It is remarkable how sensitive many patients are to a slight increase in the dosage." Considering it doesn't take much DNP to overcome any tolerance, I'd just stay on a low dose, increasing it as needed, until you reach your goals.


Hope that helps,

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A few comments... The fat loss and heat are dose-defendant. You can take a low dose and not feel hot or tired at all. With moderate doses, you can feel hot but have a body temperature below normal due to overcompensation by your body's thermoregulation. It's only with very high doses (relative to personal tolerance) that body temperature starts to rise above normal. A body temperature above normal is the #1 sign of impending toxicity. Most people on DNP have a body temperature well within the normal range.

I'd argue that yellow sweat is not a side effect of DNP. Sweat, yes. And sweat can naturally stain things yellow. But "yellow sweat" is simply not noted in either the original clinical research on DNP or in the thousands of DNP logs on the internet.

DNP permanently stains a lot of things yellow, but not everything. For example, it will come out of clothes with detergent and can be removed from some surfaces.

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With long-term administration (> 7 weeks), two factors lead to sudden cessation of weight loss (after weeks of steady, rapid weight loss):

1. Factor 1: rapidly acquired tolerance to the drug. EX:

One patient, on a daily dose of 320 mg, resulting in a RMR ↑26%, lost weight at an average rate of 1.4 kg (3 lb) weekly x 7 weeks. Then, for 6 weeks, she lost no weight even though the dose was raised to 400 mg daily. A RMR determination at this time showed that RMR ↑ by a mere 6% (relatively rare)
The acquired tolerance is rapidly lost if the drug is discontinued for as short a period as two weeks. The dinitrophenol may then be resumed at a lower dosage level with its original effect on the patient.

2. Factor 2: Edema (profound); DNP promotes water storage in the tissues of the body. EX:

Another patient, on a daily dose of 300 mg, resulting in a RMR ↑46%, lost an average of 0.9 kg (2 lb) weekly x 8 weeks. Then, she suddenly stopped losing weight. The dosage was increased to 400 mg daily x 4 weeks with no resultant weight loss. A RMR determination at this time showed that RMR ↑ by a considerable 62% (common)

Naturally, cessation from DNP at such a time results in dramatic water, and therefore weight, loss.

[12] Simkins, S. (1937). Dinitrophenol and dessicated thyroid in the treatment of obesity. Journal of the American Medical Association, 108(25), 2110. doi:10.1001/jama.1937.02780250024006

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Beti ona said:

A study showed that a 2 week break resets your DNP tolerance and makes low doses effective again. In the old obesity studies, participants would either take short breaks like this or increase their dose over time to maintain the same rate of fat loss.

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Dr. Cutting and Dr. Tainter worked with thousands of obese patients in the 1930s.

Some of their patients stayed on DNP for months or even years. They were taking it to lose large amounts of weight, though. They didn't study bodybuilders trying to cut from 15% to 6%.

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MS1605 said:

Beti, do you know what study it was that showed this?

Every study that I have read to my knowledge all said that there is absolutely no tolerance that builds up and the rate of fat loss on day 1 is the same as day 100. The bro science has seemed to echo this.

I have personally witnessed the exact opposite of this with the 4 guys I know that cycle during the year. The effectiveness always seems to taper but I never had any scientific data to back it up. Real curious where you read this.

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RiseUp said:

@Beti ona thank you so much for the info about DNP, the tolerance info is new for me. I would like to ask, do you use something just to cover yourself against the cataract thing? I did try calcium pyruvate but my gut doesnt like it...

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Beti ona said:

Thank you for your words, I only take 2 grams of vitamin C, It's enough, if you are a man you do not have much risk of developing cataracts.

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MS1605 said:

Beti, do you know what study it was that showed this?

Every study that I have read to my knowledge all said that there is absolutely no tolerance that builds up and the rate of fat loss on day 1 is the same as day 100. The bro science has seemed to echo this.

I have personally witnessed the exact opposite of this with the 4 guys I know that cycle during the year. The effectiveness always seems to taper but I never had any scientific data to back it up. Real curious where you read this.

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Beti ona said:

I always get ictericie

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Beti ona said:

Well, it is a possible effect of using DNP, it would be worse if I didn't know the cause, at the end of the day, we are taking a toxic product. But no, it's probably not good, I suspect I'll stop playing with DNP soon

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RiseUp said:

I am not Beti but this could help : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315023/?page=5
Also good read : https://sci-hub.se/10.2307/1662851

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