What arimidex dosage for high e2?

[27GShot]

I'm currently running an test-e 500mg every week (split over 250mg e3.5d). I always have high e2 when running test and it effects my libido. So I want to treat my e2 levels with arimidex to see if it gets better when I get it close to the normal range.

Currently my bloodwork for test and e2 is the following:

estradiol (17-beta-estradiol) ECLIA ↑ 579.9 pmol/l (normal range: 41.5 - 158.5)
testosterone ECLIA ↑ 168.0 nmol/l (normal range: 8.64 - 29.00)
testosterone, free RIA ↑ >364.4 (normal range: pmol/l 30.71 - 74.26)

I'm not sure what dose of arimidex to take. I'm thinking about 0.5mg every 3.5 days. But since my e2 seems quite high, maybe a higher dose is better in my case?

What do you guys recommend in my case?

 

[MisterSuperGod]

i would suggest what you're suggesting. Take it on injection days and don't start with a higher dose or anything like that.

 

[beefnewton]

I hate these units. I don't really see your E2 as that high, relative to your total Test. It's actually a decent ratio. Are you having any symptoms? Yea, as an absolute value, it's high, but your total Test is 4800+ (E2 is 158).

 

[27GShot]

I hate these units. I don't really see your E2 as that high, relative to your total Test. It's actually a decent ratio. Are you having any symptoms? Yea, as an absolute value, it's high, but your total Test is 4800+ (E2 is 158).

Yes, I get libido issues when my e2 gets high. Or at least, I assume it's because of the e2.

Low libido and dick gets softer during sex, which is quite annoying... I tried taking cialis, which did help a lot. But I feel like it worth trying to lower my e2 to see if that brings any benefits as well.

 

[beefnewton]

I'm gonna bow out then. You're in area of test usage where I have little experience. I tend to think of things in a TRT context. MSG has better advice.

 

[27GShot]

i would suggest what you're suggesting. Take it on injection days and don't start with a higher dose or anything like that.

Thanks, then I will at least start with 0.5mg e3.5d on injection days. I'll do bloodwork after a few weeks to see where I'm at.

Any other ideas or suggestions are always welcome.

 

[notsoswoleCPA]

The bad thing is it also depends on your SHBG. You can literally have above normal estradiol levels if your SHBG runs high with no ill side effects. I know because my SHBG used to run high. The bad thing about high SHBG is it also binds up all your free testosterone, requiring a larger than normal dose just to get adequate free testosterone.


Making matters worse, the only thing that I have taken to date that effectively lowered my SHBG was Anavar. I can always count on the var to tank my SHBG and lipids. Woo hoo!

 

[27GShot]

I forgot to add my SHBG, but I also did bloodwork for that. My SHBG is still it the normal range. It never seems to change when I blast a cycle. When I'm on a cruise it's also around this range.

SHBG (sex.horm.bind. gl.) ECLIA 30.4 nmol/l (normal range: 18.3 - 54.1)

 

[notsoswoleCPA]

I only have experience with Anastrozole and I would take 1 mg per week when running my testosterone at 500 mg. EDIT: Of course, I waited until the high estradiol symptoms kicked in first. With me that was usually excess fluid retention.

 

[Send0]

High E2, and side effects are individual. For example I could let my E2 run that high, with that same level total test... but then if I had your total test levels then my free test tends to come back literally 17x higher than what you show.

See my attached screenshot, not just for the value shown but also to understand why your testing method is inaccurate, which I will explain further. BTW; free test 1764 pg/ml = 6490 pmol/L, total test 4244 ng/dL = 147 nmol/L, and E2 152 pg/ml = 558 pmol/L. My E2 in the screenshot was an anomaly for me, as my E2 is almost never that high... But this particular test was close to the numbers you listed so I thought I'd use myself as an example.

With that said, the method of testing you used for E2 and free test are not accurate. You can get away with CLIA and RIA for the total testosterone and total estrogen, if all you're running is testosterone. However these testing methods can be wildly inaccurate for testing specific markers like free testosterone and estradiol.

You need to use LC/MS-MS testing. It is the most accurate measurement. You should do this before getting on an AI, because it's possible that your E2 is lower than what the CLIA testing method shows. If so, then you could end up tanking E2 by taking an AI... and then you'll be even more confused as to what is going on with your body.

 

[Jonjon]

Send0 is correct. I order the estradiol ultra sensitive test when I order from Ulta labs.

Half an adex twice a week should get you feeling better. If that’s not enough, split to MWF injections and try a half with each injection. I like to take my adex about 12 hours after my shot with cypionate or enanthate.

 

[27GShot]

High E2, and side effects are individual. For example I could let my E2 run that high, with that same level total test... but then if I had your total test levels then my free test tends to come back literally 17x higher than what you show.

See my attached screenshot, not just for the value shown but also to understand why your testing method is inaccurate, which I will explain further. BTW; free test 1764 pg/ml = 6490 pmol/L, total test 4244 ng/dL = 147 nmol/L, and E2 152 pg/ml = 558 pmol/L. My E2 in the screenshot was an anomaly for me, as my E2 is almost never that high... But this particular test was close to the numbers you listed so I thought I'd use myself as an example.

With that said, the method of testing you used for E2 and free test are not accurate. You can get away with CLIA and RIA for the total testosterone and total estrogen, if all you're running is testosterone. However these testing methods can be wildly inaccurate for testing specific markers like free testosterone and estradiol.

You need to use LC/MS-MS testing. It is the most accurate measurement. You should do this before getting on an AI, because it's possible that your E2 is lower than what the CLIA testing method shows. If so, then you could end up tanking E2 by taking an AI... and then you'll be even more confused as to what is going on with your body.

Thanks for the elaborate answer. I had no idea that there are better testing methods for (free) test and e2. I will definitely use those methods next time to make sure the values I get back are more accurate.

In the mean time I will start with the suggested adex protocol, because I do feel shitty. Since I only use test-e and nothing else I'm sure my e2 is elevated. Will do bloodwork in a week or 3 to see where my levels are at.

 

[Hunked]

I'm currently running an test-e 500mg every week (split over 250mg e3.5d). I always have high e2 when running test and it effects my libido. So I want to treat my e2 levels with arimidex to see if it gets better when I get it close to the normal range.

Currently my bloodwork for test and e2 is the following:

estradiol (17-beta-estradiol) ECLIA ↑ 579.9 pmol/l (normal range: 41.5 - 158.5)
testosterone ECLIA ↑ 168.0 nmol/l (normal range: 8.64 - 29.00)
testosterone, free RIA ↑ >364.4 (normal range: pmol/l 30.71 - 74.26)

I'm not sure what dose of arimidex to take. I'm thinking about 0.5mg every 3.5 days. But since my e2 seems quite high, maybe a higher dose is better in my case?

What do you guys recommend in my case?

.5mg twice per week and see how your body responds.

 

[GreatGunz]

My E2 is about the same on 200 mg of test.
I only really pay attention when my progesterone is affecting me.