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Hmm. Most of the data re TB-500 & eyes is positive - helps with dry eyes, corneal healing, etc. If it was directly responsible for your eye color switching then it would involve structural changes in the iris, melanin production from a genomic level, stuff like that. Of course nothing of the kind has ever been documented so this is very much me grasping at straws.
Or it might have nothing to do with TB-500 at all. Eye color has been known to change from blue to green depending on a persons mood (yes, really).
Happens to me occasionally. My daughter especially notices my change in eye color.